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Antivenin Polyvalent Side Effects

Generic name: antivenin (crotalidae) polyvalent

Medically reviewed by Last updated on Oct 28, 2022.

Note: This document contains side effect information about antivenin (crotalidae) polyvalent. Some dosage forms listed on this page may not apply to the brand name Antivenin Polyvalent.

Applies to antivenin (crotalidae) polyvalent: intravenous powder for solution.

Serious side effects

Along with its needed effects, antivenin (crotalidae) polyvalent (the active ingredient contained in Antivenin Polyvalent) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking antivenin (crotalidae) polyvalent:

Less common

  • Bruising
  • cough
  • difficulty in moving
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • feeling of discomfort
  • fever
  • hives, itching, skin rash
  • joint pain or swelling
  • large, flat, blue or purplish patches in the skin
  • muscle cramps, pain, or stiffness
  • problems with bleeding or clotting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • swollen lymph glands
  • tightness in the chest
  • unusual tiredness or weakness


  • Blurred vision
  • chest pain or discomfort
  • confusion
  • difficulty breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • noisy breathing
  • rapid, shallow breathing
  • sweating

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • itching, swelling, redness, tenderness, or hard lump at the injection site
  • pinpoint red spots on the skin
  • tremor
  • unusual bleeding or bruising

Other side effects

Some side effects of antivenin (crotalidae) polyvalent may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


For Healthcare Professionals

Applies to antivenin (crotalidae) polyvalent: injectable solution, intravenous powder for injection.


The most common adverse events were urticaria and rash.


Very common (10% or more): Urticaria (16%), rash (11%)

Common (1% to 10%): Pruritus, cellulitis, subcutaneous nodule, ecchymosis

Postmarketing reports: Erythema, hyperhidrosis, angioedema


Allergic reaction consisted of urticaria, dyspnea, and wheezing. Serum sickness included urticaria, cough, rash, pruritus, and urticaria. Acute allergic reactions manifested as anxiety, bronchospasm, chills, edema, fever, hypotension, pruritus, rash, urticaria, voice alteration, and/or wheezing.[Ref]

Common (1% to 10%): Allergic reaction, serum sickness

Postmarketing reports: Acute allergic reactions including anaphylaxis or anaphylactoid reactions, delayed allergic reaction.[Ref]


Common (1% to 10%): Coagulation disorder

Postmarketing reports: Delayed or recurrent coagulopathy or thrombocytopenia, thrombocytopenia refractory to treatment, bleeding


Common (1% to 10%): Hypotension

Postmarketing reports: Tachycardia

Nervous system

Common (1% to 10%): General paresthesia, nervousness

Postmarketing reports: Tremor, dizziness, headache[Ref]


Common (1% to 10%): Asthma, cough, increased sputum

Postmarketing reports: Tachypnea, bronchospasm, wheezing, tracheal edema, dyspnea


Common (1% to 10%): Back pain, myalgia

Postmarketing reports: Musculoskeletal chest pain, chills


Common (1% to 10%): Nausea, anorexia, circumoral paresthesia

Postmarketing reports: Tongue swelling, lip swelling


Common (1% to 10%): Chest pain, wound infection, chills

Postmarketing reports: Failure to achieve initial control, recurrent swelling refractory to treatment, prolonged hospitalization, treatment failure resulting in death, chest discomfort, swelling


Common (1% to 10%): Nervousness


Postmarketing reports: Worsening eye sight

More about Antivenin Polyvalent (antivenin (crotalidae) polyvalent)

Patient resources

Other brands

Anavip, CroFab

Professional resources

Related treatment guides


1. "Product Information. CroFab (antivenin (Crotalidae) polyvalent)." Savage Laboratories

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.