Antihemophilic Factor/von Willebrand Factor Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 11, 2024.

Applies to antihemophilic factor/von willebrand factor: intravenous powder for solution.

Precautions

It is very important that your doctor check you closely while you or your child are receiving this medicine to make sure it is working properly. Blood tests may be needed to check for unwanted effects.

Call your doctor right away if this medicine does not prevent or stop bleeding as expected.

This medicine may cause serious allergic reactions including anaphylaxis. These can be life-threatening and require immediate medical attention. Tell your doctor right away if you or your child have a cough, difficulty with swallowing, dizziness, a fast heartbeat, trouble breathing, chest tightness, swelling in your face, hands, tongue, or throat, a fever, chills, a runny nose or sneezing, itching or hives, or lightheadedness or faintness after you get the injection.

This medicine may increase your chance of having blood clots. Tell your doctor right away if you or your child have a sudden or severe headache, problems with vision or speech, chest pain, trouble breathing, or numbness or weakness after receiving this medicine.

This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made from human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the making of these medicines. Although the risk is low, talk with your doctor if you have concerns.

Serious side effects

Along with its needed effects, antihemophilic factor/von willebrand factor may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking antihemophilic factor/von willebrand factor:

For healthcare professionals

Applies to antihemophilic factor/von willebrand factor: intravenous powder for injection.

General adverse events

The most serious side effects were anaphylaxis/hypersensitivity reactions.^[Ref]

Immunologic

• Common (1% to 10%): Allergy, infection, hypersensitivity
• Uncommon (0.1% to 1%): Factor VIII inhibition
• Very rare (less than 0.01%): Von Willebrand factor inhibition, anaphylactic shock
• Frequency not reported: Allergic-anaphylactic reactions, sepsis^[Ref]

Other

• Very common (10% or more): Pain (up to 17.5%)
• Common (1% to 10%): Fever, surgery, facial edema, chest pain, peripheral edema, rigors
• Frequency not reported: Chills, pseudothrombocytopenia, postoperative pain
• Postmarketing reports: Fatigue, malaise^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 23.8%), constipation (11.1%)
• Common (1% to 10%): Gastrointestinal bleeding, abdominal pain, vomiting
• Frequency not reported: Postoperative nausea^[Ref]

Hematologic

• Common (1% to 10%): Groin bleed, ear bleed, shoulder bleed, anemia/hemoglobin decreased, thromboembolic event
• Frequency not reported: Hemorrhage, hematocrit decreased, postoperative hemorrhage, postoperative wound bleeding
• Postmarketing reports: Hemolysis^[Ref]

Nervous system

• Common (1% to 10%): Cerebral hemorrhage/subdural hematoma, dizziness, headache, dysgeusia, somnolence
• Frequency not reported: Headache, paresthesia, drowsiness^[Ref]

Respiratory

• Common (1% to 10%): Epistaxis, hemoptysis, pulmonary embolus, sore throat
• Frequency not reported: Respiratory distress
• Postmarketing reports: Dyspnea, cough, sneezing, throat irritation^[Ref]

Dermatologic

• Common (1% to 10%): Sweating increased, pruritus, rash, urticaria^[Ref]

Genitourinary

• Common (1% to 10%): Menorrhagia, hematuria, urinary retention, urinary tract infection^[Ref]

Hepatic

• Common (1% to 10%): ALT increased, liver function test abnormal^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, muscle and joint stiffness
• Frequency not reported: Extremity pain
• Postmarketing reports: Joint pain^[Ref]

Cardiovascular

• Common (1% to 10%): Thrombophlebitis
• Frequency not reported: Orthostatic hypotension, phlebitis, vasodilation, bradycardia, palpitations^[Ref]

Local

• Common (1% to 10%): Infusion site erythema or rash or pain
• Frequency not reported: Injection site bleeding
• Postmarketing reports: Infusion site pain^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia^[Ref]

Ocular

• Frequency not reported: Blurred vision^[Ref]

Renal

• Frequency not reported: Pyelonephritis^[Ref]

Metabolic

• Postmarketing reports: Hypervolemia^[Ref]

See also:

Further information

Antihemophilic factor/von willebrand factor side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer