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Ak-Pentolate Side Effects

Generic name: cyclopentolate ophthalmic

Medically reviewed by Last updated on Jul 11, 2023.

Note: This document contains side effect information about cyclopentolate ophthalmic. Some dosage forms listed on this page may not apply to the brand name Ak-Pentolate.

Applies to cyclopentolate ophthalmic: ophthalmic solution.

Serious side effects of Ak-Pentolate

Along with its needed effects, cyclopentolate ophthalmic (the active ingredient contained in Ak-Pentolate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking cyclopentolate ophthalmic:

Symptoms of too much medicine being absorbed into the body

Other side effects of Ak-Pentolate

Some side effects of cyclopentolate ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For Healthcare Professionals

Applies to cyclopentolate ophthalmic: compounding powder, ophthalmic solution.


Local irritation may occur following instillation and the frequency is dependent upon the concentration used.[Ref]


Frequency not reported: Intraocular pressure increased, burning, photophobia, vision blurred, irritation, hyperemia, conjunctivitis, blepharoconjunctivitis, punctate keratitis, synechiae, redness of eyes, lacrimation, mucus discharge, allergic conjunctivitis, eye pruritus

Postmarketing reports: Mydriasis prolonged, eye irritation, eye pain[Ref]

Nervous system

Frequency not reported: Ataxia, incoherent speech, hyperactivity, seizure, drowsiness, coma, medullary paralysis, convulsion, somnolence, incoordination, poor balance, tremor

Postmarketing reports: Retrograde amnesia, dizziness, headache[Ref]


Frequency not reported: Secretion decreased in pharynx/bronchi/nasal passages[Ref]


Frequency not reported: Tachycardia, vasodilation[Ref]


Frequency not reported: Skin rash, flushing, dry skin

Postmarketing reports: Erythema[Ref]


Frequency not reported: Abdominal distention infants, gastrointestinal motility diminished, salivary secretion decreased, sweat gland secretion decreased, necrotizing colitis, gastroenteritis, dry mouth

Postmarketing reports: Nausea, vomiting[Ref]


Frequency not reported: Urinary retention[Ref]


Frequency not reported: Restlessness, hallucination, disorientation, failure to recognize people

Postmarketing reports: Confusion, agitation[Ref]


Postmarketing reports: Hypersensitivity[Ref]


Frequency not reported: Feeding intolerance[Ref]


Frequency not reported: Hyperpyrexia, death, vertigo

Postmarketing reports: Pyrexia, fatigue, gait disturbed[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2006) "Product Information. Cyclopentolate Hydrochloride (cyclopentolate ophthalmic)." Falcon Ophthalmics

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.