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Aflibercept ophthalmic Side Effects

In Summary

More frequently reported side effects include: increased intraocular pressure. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to aflibercept ophthalmic: intraocular solution

In addition to its needed effects, some unwanted effects may be caused by aflibercept ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking aflibercept ophthalmic, check with your doctor or nurse immediately:

More common:
  • Blindness
  • bloody eye
  • blurred vision
  • eye or eyelid redness
  • eye pain
  • seeing flashes, sparks of light, or a veil or curtain
  • seeing floating spots before the eyes
  • vision changes
Less common:
  • Bleeding or pain at the injection site
  • swelling of the eyelid
  • Fast heartbeat
  • fever
  • headache
  • hives, itching, rash, or skin redness
  • hoarseness
  • joint pain, stiffness, or swelling
  • swelling of the face, lips, hands, or feet
  • troubled breathing or swallowing
Incidence not known:
  • Pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath

Minor Side Effects

Some of the side effects that can occur with aflibercept ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Feeling like something is in the eye
  • watery eyes

For Healthcare Professionals

Applies to aflibercept ophthalmic: intraocular solution


Very common (10% or more): Conjunctival hemorrhage (28%), eye pain (13%),
Common (1% to 10%): Cataract, vitreous floaters, corneal erosion, intraocular pressure increased, conjunctival hyperemia, ocular hyperemia, vitreous detachment, foreign body sensation in eyes, lacrimation increased, vision blurred, intraocular inflammation, retinal pigment epithelium tear, injection site hemorrhage, eyelid edema, corneal edema, retinal degeneration, cataract, cataract nuclear, cataract subcapsular, corneal abrasion, intraocular pressure increased, vitreous floaters
Uncommon (0.1% to 1%): Retinal detachment, retinal tear, endophthalmitis injection site pain, traumatic cataract[Ref]


Common (1% to 10%): Injection site pain[Ref]


Postmarketing reports:
Common (1% to 10%): Arterial thromboembolic events (ATEs) (such as nonfatal stroke, nonfatal myocardial infarction, or vascular death)[Ref]


Uncommon (0.1% to 1%): Hypersensitivity


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Eylea (aflibercept ophthalmic)." Regeneron Pharmaceuticals Inc, Tarrytown, NY.

Not all side effects for aflibercept ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.