Skip to Content

Aflibercept ophthalmic Side Effects

In Summary

More frequently reported side effects include: increased intraocular pressure. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to aflibercept ophthalmic: intraocular solution

Along with its needed effects, aflibercept ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking aflibercept ophthalmic:

More Common

  • Blindness
  • bloody eye
  • blurred vision
  • eye or eyelid redness
  • eye pain
  • seeing flashes, sparks of light, or a veil or curtain
  • seeing floating spots before the eyes
  • vision changes

Less Common

  • Bleeding or pain at the injection site
  • swelling of the eyelid


  • Fast heartbeat
  • fever
  • headache
  • hives, itching, rash, or skin redness
  • hoarseness
  • joint pain, stiffness, or swelling
  • swelling of the face, lips, hands, or feet
  • troubled breathing or swallowing

Incidence Not Known

  • Pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath

Some side effects of aflibercept ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

For Healthcare Professionals

Applies to aflibercept ophthalmic: intraocular solution


Very common (10% or more): Conjunctival hemorrhage (28%), eye pain (13%),

Common (1% to 10%): Cataract, vitreous floaters, corneal erosion, intraocular pressure increased, conjunctival hyperemia, ocular hyperemia, vitreous detachment, foreign body sensation in eyes, lacrimation increased, vision blurred, intraocular inflammation, retinal pigment epithelium tear, injection site hemorrhage, eyelid edema, corneal edema, retinal degeneration, cataract, cataract nuclear, cataract subcapsular, corneal abrasion, intraocular pressure increased, vitreous floaters

Uncommon (0.1% to 1%): Retinal detachment, retinal tear, endophthalmitis injection site pain, traumatic cataract[Ref]


Common (1% to 10%): Injection site pain[Ref]


Postmarketing reports:

Common (1% to 10%): Arterial thromboembolic events (ATEs) (such as nonfatal stroke, nonfatal myocardial infarction, or vascular death)[Ref]


Uncommon (0.1% to 1%): Hypersensitivity


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Eylea (aflibercept ophthalmic)." Regeneron Pharmaceuticals Inc, Tarrytown, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.