Does Eylea and Eylea HD raise blood pressure?

Eylea and Eylea HD injections into the eye (intravitreal) are associated with a substantial but temporary increase in blood pressure in some patients.

One study of 201 patients reported that 72% of patients (n=144) had a mean systolic blood pressure increase of 10 mmHg or more and 46% (n=93) had a systolic BP increase of 20 mmHg or more. 11% (23 patients) had their blood pressure increase to over 200 mmHg which is associated with an increased risk of cardiovascular and cerebrovascular events. Blood pressure returned to near baseline levels approximately 5 minutes after the injection. The mean pulse rate also increased from 76 bpm to 80 bpm. Consider perioperative blood pressure monitoring or increased antihypertensive treatment in people at high risk for cardiovascular or cerebrovascular events undergoing intravitreal Eylea or Eylea HD injections.

Increases in intraocular pressure (the pressure inside the eye) have also been seen within 60 minutes of an injection of Eylea or Eylea HD. These pressure increases are usually temporary, but there is an increased risk of them becoming more sustained with repeated dosing of Eylea or Eylea HD. Because sustained intraocular pressure affects blood flow to the optic nerve and is associated with an increased risk of glaucoma, patients should be monitored and managed appropriately.