Generic Name: ribavirin (oral) (rye ba VYE rin)
Brand Names: Copegus, Moderiba, Rebetol, RibaPak, Ribasphere, RibaTab
Medically reviewed on November 6, 2017
What is Ribasphere?
Ribasphere (ribavirin) is an antiviral medication.
Ribasphere must be used together with an interferon alfa product (such as Pegasys, PegIntron, Sylatron, or Intron A) to treat chronic hepatitis C.
Ribasphere may also be used for purposes not listed in this medication guide.
You should not use Ribasphere if you have autoimmune hepatitis, severe kidney disease, or a hemoglobin blood cell disorder.
Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, weakness, or trouble breathing.
Ribasphere is not effective when used alone. It must be used together with an interferon alfa product. You should not take ribavirin with didanosine.
Ribavirin can cause birth defects or death in an unborn baby. Do not use this medicine if you are pregnant, or if you are a man and your sexual partner is pregnant. Use 2 forms of birth control to prevent pregnancy while either sexual partner is taking Ribasphere, and for at least 6 months after treatment ends. Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking Ribasphere.
In rare cases, ribavirin can cause fatal heart problems. Get emergency medical attention if you have chest pain.
Before taking this medicine
You should not take Ribasphere if you are allergic to ribavirin, or if you have:
a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia;
severe kidney disease;
if you are also taking didanosine (Videx); or
if you are pregnant, or if you are a man whose sexual partner is pregnant.
You should not take Ribasphere with peginterferon alfa-2a if you have:
autoimmune hepatitis; or
severe liver disease (especially cirrhosis).
To make sure Ribasphere is safe for you, tell your doctor if you have:
a blood cell disorder such as anemia (low red blood cells);
liver problems other than hepatitis C;
a thyroid disorder;
human immunodeficiency virus (HIV or AIDS);
a history of depression, mental illness, or suicide attempt;
a history of organ transplant; or
if you have ever received treatment for hepatitis C that did not work well.
Ribasphere can cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before taking this medicine and every month during your treatment.
If you are a woman, do not take Ribasphere if you are pregnant.
If you are a man, do not take Ribasphere if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin.
Use at least 2 effective forms of birth control to prevent pregnancy while either sexual partner is taking ribavirin. Keep using 2 forms of birth control for at least 6 months after treatment ends.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking Ribasphere.
If a pregnancy occurs, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of ribavirin on the baby.
It is not known whether ribavirin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Ribasphere is not approved for use by anyone younger than 3 years old.
Ribasphere can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
How should I take Ribasphere?
Take Ribasphere exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Ribasphere is not effective when used alone to treat hepatitis C. It must be used together with an interferon alfa product.
Take with food.
Do not crush, chew, break, or open a capsule. Swallow it whole. Tell your doctor if you have trouble swallowing the capsule.
Use Ribasphere regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Drink extra fluids while you are taking Ribasphere to keep from getting dehydrated, especially during exercise or in hot weather.
Ribasphere can cause dry mouth, which could lead to tooth decay or gum disease. If you vomit while taking this medicine, rinse your mouth out with water to prevent damage to your teeth or gums. Be sure to have regular dental exams while you are taking this medication.
Store at room temperature away from moisture, heat, and light.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Ribasphere?
Avoid drinking alcohol. It may increase your risk of liver damage.
Using this medicine will not prevent you from passing hepatitis to other people. Follow your doctor's instructions about how to prevent passing the disease to another person.
Ribasphere side effects
Get emergency medical help if you have signs of an allergic reaction to Ribasphere: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Ribavirin can cause anemia. In rare cases, this can lead to fatal heart problems. Get emergency medical attention if you have chest pain.
Call your doctor at once if you have:
problems with your vision;
severe pain in your upper stomach spreading to your back, nausea, vomiting, diarrhea;
stabbing chest pain, wheezing, feeling short of breath;
severe depression, thoughts about suicide, or thoughts about hurting someone else;
signs of serious anemia - pale or yellowed skin, dark colored urine, confusion or weakness; or
other signs of low blood cell counts - fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, easy bruising, unusual bleeding, feeling light-headed.
Common Ribasphere side effects may include:
nausea, flu-like symptoms, tiredness;
fever, chills or shaking;
mood changes, feeling irritable;
muscle pain; or
stomach pain, vomiting, loss of appetite.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Ribasphere?
Tell your doctor about all your current medicines and any you start or stop using, especially:
medicines to treat HIV or AIDS.
This list is not complete. Other drugs may interact with ribavirin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ribasphere only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 7.01.
More about Ribasphere (ribavirin)
- Ribasphere Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
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- Drug class: inhaled anti-infectives