Skip to Content

Sulconazole

Medically reviewed by Drugs.com. Last updated on Jun 27, 2020.

Pronunciation

(sul KON a zole)

Index Terms

  • Sulconazole Nitrate

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External, as nitrate:

Exelderm: 1% (15 g [DSC], 30 g [DSC], 60 g) [contains cetyl alcohol, propylene glycol]

Generic: 1% (60 g)

Solution, External, as nitrate:

Exelderm: 1% (30 mL) [contains propylene glycol]

Generic: 1% (30 mL)

Brand Names: U.S.

  • Exelderm

Pharmacologic Category

  • Antifungal Agent, Imidazole Derivative
  • Antifungal Agent, Topical

Pharmacology

Substituted imidazole derivative which inhibits metabolic reactions necessary for the synthesis of ergosterol, an essential membrane component. The end result is usually fungistatic; however, sulconazole may act as a fungicide in Candida albicans and Candida parapsilosis during certain growth phases.

Absorption

Topical: ~8.7% percutaneously (Franz 1988)

Excretion

Primarily urine

Use: Labeled Indications

Fungal infections:

Cream: Treatment of tinea pedis (athlete's foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; treatment of tinea versicolor

Solution: Treatment of tinea cruris and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; treatment of tinea versicolor

Limitations of use: Effectiveness has not been proven in tinea pedis (athlete's foot).

Contraindications

Hypersensitivity to sulconazole or any component of the formulation

Dosing: Adult

Tinea corporis/tinea cruris/tinea versicolor: Topical: Apply a small amount to the affected and surrounding skin areas once or twice daily for 3 weeks.

Tinea pedis: Topical: Cream: Apply a small amount to the affected area twice daily for 4 weeks.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Geriatric

Refer to adult dosing.

Administration

For external use only; avoid contact with the eyes. Apply a small amount and gently massage into affected and surrounding skin areas.

Storage

Avoid excessive heat, above 40°C (104°F); protect solution from light.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

1% to 10%:

Central nervous system: Localized burning

Dermatologic: Localized erythema, pruritus, stinging of the skin

Warnings/Precautions

Concerns related to adverse effects:

• Irritation: Discontinue if sensitivity or irritation occurs.

Other warnings/precautions:

• Appropriate use: For topical use only; avoid contact with eyes.

Pregnancy Risk Factor

C

Pregnancy Considerations

Adverse events have been observed in animal reproduction studies with large doses administered orally. Systemic absorption is limited following topical administration.

Patient Education

What is this drug used for?

• It is used to treat fungal infections of the skin.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Skin irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.