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Medically reviewed on Dec 20, 2018


(se LEE nee um)

Index Terms

  • Selenious Acid

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Selenicaps-200: 200 mcg [corn free, no artificial color(s), rye free, sugar free, wheat free, yeast free]

Capsule, Oral [preservative free]:

Se-100: 100 mcg [dye free, yeast free]

Liquid, Oral:

Aqueous Selenium: 95 mcg/drop (15 mL) [contains sodium benzoate]

Solution, Intravenous:

Generic: 40 mcg/mL (10 mL)

Tablet, Oral:

Oceanic Selenium: 50 mcg, 200 mcg [animal products free, gelatin free, gluten free, kosher certified, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Se Aspartate: 50 mcg

Se-Plus Protein: 200 mcg

Selenimin: 125 mcg [corn free, rye free, starch free, sugar free, wheat free]

Selenimin-200: 200 mcg [corn free, rye free, starch free, sugar free, wheat free, yeast free]

Generic: 50 mcg, 200 mcg

Tablet, Oral [preservative free]:

Generic: 50 mcg, 200 mcg

Tablet Extended Release, Oral [preservative free]:

Generic: 200 mcg

Brand Names: U.S.

  • Aqueous Selenium [OTC]
  • Oceanic Selenium [OTC]
  • Se Aspartate [OTC]
  • Se-100 [OTC]
  • Se-Plus Protein [OTC]
  • Selenicaps-200 [OTC]
  • Selenimin [OTC]
  • Selenimin-200 [OTC]

Pharmacologic Category

  • Trace Element, Parenteral


Part of glutathione peroxidase which protects cell components from oxidative damage due to peroxidases produced in cellular metabolism


Urine, feces, lungs, skin

Use: Labeled Indications

Trace metal supplement


Undiluted administration into peripheral vein

Dosing: Adult

Parenteral nutrition additive (Vanek 2012): IV: 60 to 100 mcg/day

Deficiency from prolonged parenteral nutrition: IV: 100 mcg/day

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Adequate intake (AI) (IOM, 2000): Oral:

1 to 6 months: 15 mcg/day

7 to 12 months: 20 mcg/day

Recommended daily allowance (RDA) (IOM, 2000): Oral:

1 to 3 years: 20 mcg/day

4 to 8 years: 30 mcg/day

9 to 13 years 40 mcg/day

14 to 18 years: 55 mcg/day

Parenteral nutrition, maintenance requirement: IV: Infants, Children, and Adolescents:

Manufacturer's labeling: 3 mcg/kg/day; maximum daily dose: 40 mcg/day

ASPEN recommendations:

Age-directed dosing (Vanek, 2012): Infants, Children, and Adolescents: 1 to 3 mcg/kg/day; maximum daily dose: 100 mcg/day

Weight-directed dosing (ASPEN Pediatric Nutrition Support Core Curriculum [Corkins, 2010]; Mirtallo, 2004):

Infants <10 kg: 2 mcg/kg/day

Children 10 to 40 kg: 1 to 2 mcg/kg/day; maximum daily dose: 60 mcg/day

Adolescents >40 kg: 40 to 60 mcg/day

Dietary Considerations

Dietary adequate intake (AI): Note: Breast milk, formula, and food should be the only sources of selenium for infants (NIH 2016)

1 to 6 months: 15 mcg/day

7 to 12 months: 20 mcg/day

Dietary recommended daily allowance (RDA) (IOM 2000):

1 to 3 years: 20 mcg/day

4 to 8 years: 30 mcg/day

9 to 13 years: 40 mcg/day

≥14 years: 55 mcg/day

Pregnancy: 60 mcg/day

Lactation: 70 mcg/day


Prior to use, store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Drug Interactions

Baloxavir Marboxil: Selenium may decrease the serum concentration of Baloxavir Marboxil. Avoid combination

Dolutegravir: Selenium may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral selenium. Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral selenium. Consider therapy modification

Eltrombopag: Selenium may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any selenium-containing product. Consider therapy modification

Adverse Reactions

Frequency not defined: Local: Local irritation


Disease-related concerns:

• Gastrointestinal dysfunction: Use with caution in patients with GI impairment.

• Renal impairment: Use with caution in patients with renal impairment.

Dosage form specific issues:

• Aluminum: The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register, 2002). See manufacturer’s labeling.

Monitoring Parameters

Plasma selenium concentration for patients receiving long-term PN (every 3 to 6 months; some patients (ie, HSCT) may require more frequent monitoring) (ASPEN Pediatric Nutrition Support Core Curriculum [Corkins 2010])

Pregnancy Risk Factor


Pregnancy Considerations

Adverse events were seen with high doses in animal studies. Selenium is found in the placenta and cord blood. Teratogenic effects have not been observed with nontoxic doses in humans (IOM, 2000).

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.