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Ferric Subsulfate

Medically reviewed by Last updated on Aug 17, 2020.


(FER ik sub SULL fate)

Index Terms

  • Monsel's Solution

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, External:

Astringyn: 259 mg/g (8 g) [contains benzalkonium chloride]

Monsels Ferric Subsulfate: (8 mL, 60 mL)

Brand Names: U.S.

  • Astringyn
  • Monsels Ferric Subsulfate

Pharmacologic Category

  • Hemostatic Agent


Causes agglutination of surface proteins resulting in hemostasis

Onset of Action

Hemostasis: ≤20 seconds

Use: Labeled Indications

Hemostatic in minor surgical procedures


There are no contraindications in the manufacturer’s labeling.

Dosing: Adult

Hemostasis: Topical: Apply evenly to wound

Dosing: Geriatric

Refer to adult dosing.


Topical: For external use only. Apply to wound using cotton applicator/swab. Avoid contact with eyes.


Store at controlled room temperature. Avoid heat and light.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined.

Dermatologic: Skin hyperpigmentation (application site)


Concerns related to adverse effects:

• Hyperpigmentation: May cause heavy pigmentation at application sites, which may result in histologic artifacts (upon rebiopsy) or in radiographic artifacts.

Other warnings/precautions:

• Appropriate use: For external use only. If inadvertent ocular administration occurs wash eye(s) immediately with large amounts of water or normal saline for approximately 15 to 20 minutes or until no evidence of solution remains.

Monitoring Parameters

Hemostasis at site of application.

Pregnancy Considerations

Ferric subsulfate is used as a hemostatic agent following cervical biopsies (Manca 1997; Tam 2005). May cause vaginal pain if leakage of solution occurs (Tam 2005). A case report also describes use following a miscarriage; fertility was not impaired and a successful pregnancy occurred 7 months later (Disu 2007).

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.