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Factor IX (Recombinant [Glycopegylated])

Pronunciation

(FAK ter nyne ree KOM be nant glye koe PEG i late ed)

Index Terms

  • N9-GP
  • Nonacog Beta Pegol
  • Rebinyn

Pharmacologic Category

  • Antihemophilic Agent

Use: Labeled Indications

Factor IX deficiency: On-demand treatment and control of bleeding episodes and for perioperative management of bleeding in adults and children with factor IX deficiency (hemophilia B)

Limitations of use: Not indicated for routine prophylaxis in the treatment of patients with hemophilia B; not indicated for immune tolerance induction in patients with hemophilia B

Contraindications

Hypersensitivity to factor IX (recombinant [glycopegylated]), hamster protein, or any component of the formulation.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

1% to 10%:

Dermatologic: Pruritus (3%)

Hypersensitivity: Hypersensitivity reaction (1%)

Local: Injection site reaction (4%)

Frequency not defined:

Hypersensitivity: Anaphylaxis

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience itching or injection site redness, edema, or pain. Have patient report immediately to prescriber signs of kidney problems (urinary retention, hematuria, change in amount of urine passed, or weight gain) or signs of blood clots (numbness or weakness on one side of the body; pain, redness, tenderness, warmth, or swelling in the arms or legs; change in color of an arm or leg; angina; shortness of breath; tachycardia; or coughing up blood) (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

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