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Coagulation factor IX

Generic name: coagulation factor IX [ koe-AG-yoo-LAY-shun-FAK-tor-NINE ]
Brand names: AlphaNine SD, Alprolix, BeneFIX, Idelvion, Ixinity, ... show all 10 brands
Dosage forms: intravenous kit (recombinant; recombinant albumin fusion protein), intravenous powder for injection (human; recombinant; recombinant fc fusion protein; recombinant glycoPEGylated)
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by Drugs.com on Aug 16, 2023. Written by Cerner Multum.

What is coagulation factor IX?

Coagulation factor IX is used to treat or prevent bleeding in people with hemophilia B. This medication is not for treating people with hemophilia A factor VIII deficiency.

Coagulation factor IX may also be used for purposes not listed in this medication guide.

Coagulation factor IX side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching; wheezing, tightness in your chest, difficult breathing, fast heartbeats, blue lips, feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Coagulation factor IX may cause serious side effects. Call your doctor at once if you have:

Common side effects of coagulation factor IX may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use coagulation factor IX if:

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

Coagulation factor IX is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.

How should I use coagulation factor IX?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects.

Coagulation factor IX is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Coagulation factor IX must be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine.

The mixture should appear clear, yellow, or colorless. Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Gently swirl but do not shake the medicine while mixing or you may ruin the medicine. Use the injection within 3 hours after mixing your dose.

You may need frequent blood tests.

In case of emergency, wear or carry medical identification to let others know you have a bleeding disorder.

Carefully follow directions on your medicine label about how to store the powder medicine and the diluent. Some forms of coagulation factor IX can be stored at room temperature, and others should be kept in a refrigerator. Do not freeze. Avoid exposing the medication to light.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Throw away any leftover coagulation factor IX once the expiration date on the label has passed.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

tranexamic acid, Hemgenix, Cyklokapron, Beqvez, Hympavzi, BeneFix, NovoSeven RT, Alprolix

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using coagulation factor IX?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect coagulation factor IX?

Other drugs may affect coagulation factor IX, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does coagulation factor ix interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.