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Cromolyn (Nasal)

Medically reviewed by Last updated on Jun 1, 2020.


(KROE moe lin)

Index Terms

  • Cromoglicate
  • Cromoglycic Acid
  • Cromolyn Sodium
  • Disodium Cromoglycate
  • DSCG
  • Sodium Cromoglicate
  • Sodium Cromoglycate

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Aerosol Solution, Nasal, as sodium:

NasalCrom: 5.2 mg/actuation (13 mL, 26 mL) [contains benzalkonium chloride, edetate disodium]

Generic: 5.2 mg/actuation (26 mL)

Brand Names: U.S.

  • NasalCrom [OTC]

Pharmacologic Category

  • Mast Cell Stabilizer


Acts locally to reduce calcium influx which decreases histamine degranulation from mast cells (Melvin 2011).

Onset of Action

Response to treatment: May occur at 1 to 2 weeks

Use: Labeled Indications

Allergic rhinitis: Prevent and relieve nasal symptoms of hay fever and other nasal allergies (eg, runny/itchy nose, sneezing, allergic stuffy nose).


OTC labeling: When used for self-medication, do not use if hypersensitive to cromolyn or any component of the formulation.

Dosing: Adult

Allergic rhinitis (treatment and prophylaxis): Intranasal: Instill 1 spray (5.2 mg) in each nostril 3 to 4 times daily; may be increased up to 6 times daily. For prophylaxis initiate prior to exposure to allergen; symptomatic relief may require 1 to 2 weeks.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Allergic rhinitis: Children ≥2 years and Adolescents: Intranasal: 1 spray in each nostril 3 to 4 times daily; maximum dose: 1 spray in each nostril 6 times/day. For prophylaxis initiate prior to exposure to allergen; symptomatic relief may require 1 to 2 weeks.


Clear nasal passages by blowing nose prior to use. For prophylaxis, initiate prior to exposure to allergen.


Store between 20°C to 25°C (68°F to 77°F). Protect from light.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined.


Dermatologic: Burning sensation of the nose

Respiratory: Nasal mucosa irritation, sneezing, stinging sensation of the nose

1% to 10%:

Central nervous system: Headache

Gastrointestinal: Unpleasant taste

Respiratory: Cough, hoarseness, post-nasal drip

<1%, postmarketing, and/or case reports: Epistaxis


Other warnings/precautions:

• Local nasal effects: Brief nasal stinging and/or sneezing may occur after use.

• Self-medication (OTC use): Consult a health care provider before use if you have fever, discolored nasal discharge, sinus pain, or wheezing. Discontinue use and consult a health care provider if shortness of breath, wheezing, chest tightness, hives, or swelling of the mouth or throat occurs; if you have new symptoms, symptoms worsen, or your symptoms do not improve within 2 weeks, or need to use for >12 weeks. Do not use to treat sinus infection, asthma, or cold symptoms.

Pregnancy Considerations

Cromolyn nasal spray may be useful for the treatment of allergic rhinitis in pregnant patients with mild or sporadic symptoms who are unable to take preferred medications (BSACI [Scadding 2017]).

Patient Education

What is this drug used for?

• It is used to ease allergy signs.

• It is used to prevent nose stuffiness.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Sneezing

• Stinging

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Shortness of breath

• Severe nasal irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.