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Generic name:  melphalan flufenamide
Dosage form: lyophilized powder for injection
Drug class: Alkylating agents

Medically reviewed by Judith Stewart, BPharm. Last updated on Aug 22, 2023.

What is Pepaxto?

Pepaxto is a prescription medicine used in combination with the medicine dexamethasone to treat adults with multiple myeloma who did not respond to or stopped responding to at least four prior medicines including at least one proteasome inhibitor, one immunomodulatory agent and one
CD38-directed antibody.

Pepaxto is not for use to prepare for transplant.

It is not known if this medicine is safe and effective in children.

Who should not take Pepaxto?

Do not receive Pepaxto if you have a history of a severe allergic reaction to melphalan flufenamide or melphalan.

Before receiving Pepaxto

Before receiving Pepaxto, tell your healthcare provider about all of your medical conditions, including if you:

Males with female partners who are able to become pregnant:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How do I use Pepaxto?

Pepaxto side effects

Pepaxto may cause serious side effects, including:

Your healthcare provider may change your dose, stop your treatment for a period of time, or completely stop your treatment if you have certain side effects.

Pepaxto may cause fertility problems in males and females, which may affect your ability to have children. Talk with your healthcare provider if you have concerns about fertility.

The most common side effects include, low blood cell counts, fatigue, nausea, diarrhea, fever, and cold-like symptoms (respiratory tract infection).

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What other drugs will affect Pepaxto?

Other drugs may interact with melphalan flufenamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

General information about the safe and effective use of Pepaxto.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your healthcare provider or pharmacist for information that is written for health professionals.

What are the ingredients in Pepaxto?

Active ingredient: melphalan flufenamide
Inactive ingredient: sucrose

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.