Medically reviewed on July 10, 2018
Scientific Name(s): Pueraria lobata (Willd) Ohwi. or P. montana (Lour.) Merr. or P. thunbergiana (Siebold & Zucc.) Benth.
Common Name(s): Kudzu , kudzu vine , Japanese arrowroot , kakka , kakkon , Kakkonto (Japan), Ge Gen , XJL (NPI-028) (China)
Current interest in kudzu centers on its use as therapy for alcoholism, although sufficient and consistent clinical trials are lacking. Estrogenic activity of kudzu is also being investigated, although clinical trials are limited.
Kudzu extract 3 g daily with 25% isoflavone content has been studied in adult heavy drinkers. In another study, 2.4 g kudzu root was given daily.
Contraindications have not yet been identified.
Information regarding safety in pregnancy and lactation is lacking.
None well documented.
A few case reports of allergy exist.
Limited data available.
Kudzu is a fast-growing vine native to the subtropical regions of China and Japan. The leaves of the plant contain 3 broad oval leaflets with purple flowers and curling tendril spikes. 1 , 2 Because kudzu produces stems that can grow to 20 m in length with extensive roots, it has been used to control soil erosion. Since its introduction to the United States, kudzu has become well established and proliferates in moist southern regions, where it grows vigorously and is now considered an invasive pest.
Kudzu was introduced to the United States in the late 1800s to control soil erosion, 3 and although widely recognized as a ground cover and fodder crop in the Western world, the plant has a long history of medicinal use in Asian cultures. Beginning in the 6th century BC, Chinese herbalists used the plant for prevention of intoxication, muscular pain, and treatment of measles. 2 , 4 Kudzu is native to Japan, China, and Fiji. 5 , 6
Numerous reports have identified chemical constituents in various plant parts of kudzu. 7 , 8 , 9 Flavonoid, isoflavonoid, and isoflavone content (including puerarin) have been identified in kudzu roots and flowers. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 Kudzu contains a high total isoflavone content compared with other isoflavone-containing herbs, with the dry root containing as much as 5.32 mg/g. 20 , 21
Oleanene triterpene glycosides, also known as kudzu saponins, have been isolated from the plant. 22 , 23 Analysis of isoflavonoid aglycones and their glycosides has been performed. 24 Robinin in kudzu leaf also has been reported. 25 Other constituents evaluated include daidzin, daidzein, genistein, genestin, 26 tectoridin, 27 kakkalide, 28 formononetin, biochanin A, and plant sterols. 2 , 6 , 29 , 30 , 31 In addition, morphological and anatomical identification studies of kudzu have been performed. 32
Uses and PharmacologyAlcoholism
Available animal studies have been reviewed. 4 , 33 , 34 Isoflavones daidzin, daidzein, and puerarin may account for the suppression of ethanol intake, and although the mechanism of action is not certain, inhibition of alcohol dehydrogenase is thought to be a major factor in kudzu's antidipsotropic activity. 30 , 34 , 35 , 36 , 37 , 38Clinical data
Few clinical trials have been conducted, with conflicting results. Kudzu extract was found to have no effect on drinking patterns or cravings in a study of 38 military veterans after 1 month of administration. 39 Whereas, another small study (N = 14) conducted over a period of several weeks was able to demonstrate reduction in the number of beers and total volume consumed among heavy alcohol drinkers. 3 , 40 The amount of isoflavone present in the extracts used in the 2 trials probably differed, thus accounting for the inconsistent results. 3Estrogenic activity
The high isoflavone content of kudzu has prompted several researchers to investigate the estrogenic activity of extracts. In vitro experiments suggest daidzein to be more potent than daidzin or puerarin. 27 Studies comparing kudzu with red clover, soybean, mung, and alfalfa sprouts found kudzu to be the most potent, 19 while another study suggested that the ethanol extract of P. lobata is less effective than P. mirifica or Mucana collettii . 21 One trial of 25 menopausal women found a decrease in the number of hot flushes per day when a multiple-ingredient preparation, including kudzu extract, was used. 41 However, a larger trial was unable to find positive effects of kudzu extract in treating menopause symptoms. 42Other uses
A kudzu ethanolic extract has been evaluated for antiproliferative activity against breast, ovarian, and cervical cancer cell lines. 43Cardiovascular
Kuzdu has been examined for its effect on vascular smooth muscle tissue, 44 potential effects in arrhythmia, ischemia, angina pectoris, 45 , 46 , 47 and antioxidant activity. 48 Clinical studies are lacking.Hepatoprotection
Biochanin A demonstrated potential hypolipidemic activity via activation of peroxisome proliferator-activated receptors in an in vitro experiment. 51Osteogenic activity
Kudzu extract increased the synthesis of alkaline phosphatase in human osteoblast cells. 52
Kudzu extract 3 g daily with 25% isoflavone content has been studied in adult heavy drinkers. 3 In another study, 2.4 g kudzu root of unknown isoflavone content was given daily. 39 A wide range of isoflavone content may exist in commercial kudzu preparations, with most containing less than 1%. 3 Based on pharmacokinetic studies in healthy adults, a 3-times-daily dosing schedule is recommended. The isoflavone puerarin was rapidly absorbed after oral administration, reaching a peak in 2 hours. 18
Information regarding safety and efficacy in pregnancy and lactation is lacking.
None well documented.
Kudzu has been used as a medicinal herb for centuries with few reported toxic adverse reactions. 30 There have been a small number of case reports of allergy, specifically maculopapular drug eruption and Stevens-Johnson syndrome-type reaction, to the kudzu-containing Kakkonto decoction. 53
The safety profile of kudzu and its extracts has yet to be defined through systematic pharmacologic screens, although traditional Chinese medicine data indicate a lack of toxicity. 45 Acute toxicity of 4 Pueraria species has been studied comparatively. 47
Bibliography1. Pueraria DC. USDA, NRCS. 2007. The PLANTS Database ( http://plants.usda.gov , February, 2008). National Plant Data Center, Baton Rouge, LA 70874-4490 USA. Accessed July 7, 2008.
2. Chevallier A . Encyclopedia of Medicinal Plants . New York, NY: DK Publishing; 1996.
3. Lukas SE , Penetar D , Berko J , et al. An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting . Alcohol Clin Exp Res . 2005;29(5):756-762.
4. Xu BJ , Zheng YN , Sung CK . Natural medicines for alcoholism treatment: a review . Drug Alcohol Rev . 2005;24(6):525-536.
5. Penso G . Inventory of Medicinal Plants Used in the Different Countries . World Health Organization, 1980.
6. Kudzu extract shows potential for moderating alcohol abuse . Am J Hosp Pharm . 1994;51(6):750.
7. Kurihara T , Kiruchi M . Studies on the constituents of flowers. I. On the components of flower of Pueraria thunbergiana Benth [in Japanese]. Yakugaku Zasshi . 1973;93(9):1201-1205.
8. Kurihara T , Kiruchi M . Studies on the constituents of flowers. VI. On the components of the flower of Pueraria thubergiana Benth [in Japanese]. Yakugaku Zasshi . 1976;96(12):1486-1488.
9. Chen MH . Studies on the chemical constituents of Pueraria lobata [in Chinese]. Zhong Yao Tung Bao . 1985;10(6):34-36.
10. Saĭiad SA , Borysov MI . Flavonoids of the flowers of Pueraria lobata [in Ukranian]. Farm Zh . 1978;(6):83-84.
11. Saĭiad SA , Borysov MI . Flavonoids of the rhizomes of Pueraria [in Ukranian]. Farm Zh . 1979;(2):76-77.
12. Xu LX , Liu AR , Zhang XQ . Differential pulse polarographic determination of flavonoids in Pueraria lobata [in Chinese]. Yao Xue Xue Bao . 1987;22(3):208-211.
13. Ohshima Y , Okuyama T , Takahashi K , Takizawa T , Shibata S . Isolation and high performance liquid chromatography (HPLC) of isoflavonoids from the Pueraria root . Planta Med . 1988;54(3):250-254.
14. Kubo M , Sasaki M , Namba K , Naruto S , Nishimura H . Isolation of a new isoflavone from Chinese Pueraria flowers . Chem Pharm Bull (Tokyo) . 1975;23(10):2449-2451.
15. Kurihara T , Kikuchi M . Studies on the constituents of flowers. V. On the components of flower of Pueraria thunbergiana benth. (2). Isolation of a new isoflavone glycoside [in Japanese]. Yakugaku Zasshi . 1975;95(11):1283-1285.
16. Zhao SP , Zhang YZ . Quantitative TLC-densitometry of isoflavones in Pueraria lobata (Willd) Ohwi [in Chinese]. Yao Xue Xue Bao . 1985;20(3):203-208.
17. Ma Z , Wu Q , Lee DY , Tracy M , Lukas SE . Determination of puerarin in human plasma by high performance liquid chromatography . J Chromatogr B Analyt Technol Biomed Life Sci . 2005;823(2):108-114.
18. Penetar DM , Teter CJ , Ma Z , Tracy M , Lee DY , Lukas SE . Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers . J Altern Complement Med . 2006;12(6):543-548.
19. Boué SM , Wiese TE , Nehls S , et al. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens . J Agric Food Chem . 2003;51(8):2193-2199.
20. Hayashino Y . Is herbal "root" effective for reducing alcohol drinking? Alcohol Clin Exp Res . 2005;29(10):1913.
21. Cherdshewasart W , Cheewasopit W , Picha P . The differential anti-proliferation effect of white ( Pueraria mirifica ), red ( Butea superba ), and black ( Mucuna collettii ) Kwao Krua plants on the growth of MCF-7 cells . J Ethnopharmacol . 2004;93(2-3):255-260.
22. Arao T , Kinjo J , Nohara T , Isobe R . Oleanene-type triterpene glycosides from Puerariae radix . II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination . Chem Pharm Bull (Tokyo) . 1995;43(7):1176-1179.
23. Arao T , Kinjo J , Nohara T , Isobe R . Oleanene-type triterpene glycosides from Puerariae radix . IV. Six new saponins from Pueraria lobata . Chem Pharm Bull (Tokyo) . 1997;45(2):362-366.
24. Rong H , De Keukeleire D , De Cooman L , Baeyens WR , Van der Weken G . Narrow-bore HPLC analysis of isoflavonoid aglycones and their O- and C-glycosides from Pueraria lobata . Biomed Chromatogr . 1998;12(3):170-171.
25. Saĭiad SA , Borysov MI , Koval'ov VM . Isolation, identification and quantitative determination of robinin in the leaves of Pueraria lobata [in Ukranian]. Farm Zh . 1979;(4):52-55.
26. Lal A , Warber S , Kirakosyn A , Kaufman PB , Kim DH . Upregulation of isoflavonoids and soluble proteins in edible legumes by light and fungal elicitor treatments . J Altern Complement Med . 2003;9(3):371-378.
27. Park EK , Shin J , Bae EA , Lee YC , Kim DH . Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana . Biol Pharm Bull . 2006;29(12):2432-2435.
28. Lee HU , Bae EA , Kim DH . Hepatoprotective effects of irisolidone on tert-butyl hyperoxide-induced liver injury . Biol Pharm Bull . 2005;28(3):531-533.
29. Keung WM , Vallee BL . Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase . Proc Natl Acad Sci U S A . 1993;90(4):1247-1251.
30. Keung WM . Biochemical studies of a new class of alcohol dehydrogenase inhibitors from Radix puerariae . Alcohol Clin Exp Res . 1993;17(6):1254-1260.
31. Bruneton J . Pharmacognosy, Phytochemistry, Medicinal Plants . Paris: Lavoisier Publishing, 1995.
32. Kartmazova DS , Tkachenko NM , Borysov MI , Saiiad SA . Morphological and anatomical diagnosis of the subterranean vegetative organs of Pueraria lobata . I [in Ukranian]. Farm Zh . 1980;(3):61-63.
33. Rezvani AH , Overstreet DH , Perfumi M , Massi M . Plant derivatives in the treatment of alcohol dependency . Pharmacol Biochem Behav . 2003;75(3):593-606.
34. Keung, WM . Anti-dipsotropic isoflavones: the potential therapeutic agents for alcohol dependence . Med Res Rev . 2003;23 (6):669-696.
35. Keung WM , Vallee BL . Daidzin and daidzein suppress free-choice ethanol intake by Syrian golden hamsters . Proc Natl Acad Sci U S A . 1993;90(21):10008-10012.
36. Keung WM , Vallee BL . Kudzu root: an ancient Chinese source of modern antidipsotropic agents . Phytochemistry . 1998;47(4):499-506.
37. Xie CI , Lin RC , Antony V , et al. Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication . Alcohol Clin Exp Res . 1994;18(6):1443-1447.
38. Lin RC , Li TK . Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats . Am J Clin Nutr . 1998;68(suppl 6):1512S-1515S.
39. Shebek J , Rindone JP . A pilot study exploring the effect of kudzu root on the drinking habits of patients with chronic alcoholism . J Altern Complement Med . 2000;6(1):45-48.
40. Herbal treatment helps curb urge to drink . Harv Womens Health Watch . 2005;13(1):6-7.
41. Lukaczer D , Darland G , Tripp M , et al. Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial . Altern Ther Health Med . 2005;11(5):60-65.
42. Woo J , Lau E , Ho SC , et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause . Menopause . 2003;10(4):352-361.
43. Jeon GC , Park MS , Yoon DY , Shin CH , Sin HS , Um SJ . Antitumor activity of spinasterol isolated from Pueraria roots . Exp Mol Med . 2005;37(2):111-120.
44. Wang LY , Zhao AP , Chai XS . Effects of puerarin on cat vascular smooth muscle in vitro [in Chinese]. Zhongguo Yao Li Xue Bao . 1994;15(2):180-182.
45. Qicheng F . Some current study and research approaches relating to the use of plants in the traditional Chinese medicine . J Ethnopharmacol . 1980;2(1):57-63.
46. Lai XL , Tang B . Recent advances in the experimental study and clinical application of Pueraria lobata (Willd) Ohwi [in Chinese]. Zhongguo Zhong Yao Za Zhi . 1989;14(5):277, 308-311.
47. Zhou Y , Su X , Cheng B , Jiang J , Chen H . Comparative study on pharmacological effects of various species of Pueraria [in Chinese]. Zhongguo Zhong Yao Za Zhi . 1995;20(10):619-621, 640.
48. Sato T , Kawamoto A , Tamura A , Tatsumi Y , Fujii T . Mechanism of antioxidant action of pueraria glycoside (PG)-1 (an isoflavonoid) and magiferin (a xanthonoid) . Chem Pharm Bull (Tokyo) . 1992;40(3):721-724.
49. Arao T , Udayama M , Kinjo J , Nohara T , Funakoshi T , Kojima S . Preventive effects of saponins from Puerariae radix (the root of Pueraria lobata Ohwi) on in vitro immunological injury of rat primary hepatocyte cultures . Biol Pharm Bull . 1997;20(9):988-991.
50. Arao T , Udayama M , Kinjo J , Nohara T . Preventive effects of saponins from the Pueraria lobata root on in vitro immunological liver injury of rat primary hepatocyte cultures . Planta Med . 1998;64(15):413-416.
51. Shen P , Liu MH , Ng TY , Chan YH , Yong EL . Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii , on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro . J Nutr . 2006;136(4):899-905.
52. Huh JE , Yang HR , Park DS , et al. Puerariae radix promotes differentiation and mineralization in human osteoblast-like SaOS-2 cells . J Ethnopharmacol . 2006;104(3):345-350.
53. Akita H , Sowa J , Makiura M , Akamatsu H , Matsunaga K . Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction) . Contact Dermatitis . 2003;48(6):348-349.
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