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SAMe

Medically reviewed by Drugs.com. Last updated on Jan 22, 2019.

What are other common names?

  • ADE-SD4
  • Ademetionine
  • Adenosylmethionine
  • Adomet
  • S-Adenosyl Methionine
  • S-Adenosyl-L-Methionine
  • S-Adenosylmethionine
  • S-Adenosylmethionine Butanedisulfonate
  • S-Adenosylmethionine Tosylate Disulfate
  • S-Adénosylméthionine
  • SAdenosylmethionine Tosylate
  • SAM
  • SAM-e
  • Samesadenosylmethionine
  • Sammy

What is this product used for?

Samesadenosylmethionine is also known as SAMe. It is used by some people to help with low mood or Alzheimer disease. Others believe it helps with arthritis. Some use it to help with heart or liver problems. SAMe is used by some people to help with fibromyalgia or for sexual dysfunction.

What are the precautions when taking this product?

  • Always check with your doctor before you use a natural product. Some products may not mix well with drugs or other natural products.

  • Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests.

  • Do not take if you have bipolar depression.

  • Take extra care if you are taking drugs that effect serotonin.

  • Take extra care if you are taking drugs to thin your blood. These are drugs like warfarin (Coumadin), heparin, or enoxaparin (Lovenox).

  • Take extra care if you are taking drugs to dissolve blood clots. These are drugs like alteplase (Activase), reteplase (Retavase), or streptokinase.

  • Take extra care if you are taking drugs to help with swelling or inflammation. These are drugs like nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, ibuprofen (Advil), or naproxen (Naprosyn).

  • Take extra care and check with your doctor if you have:

    • Bleeding problems

    • Mental problems like bipolar disorder or schizophrenia

    • ADHD

    • Low mood

    • Parkinson's disease

What should I watch for?

  • Upset stomach

  • Hard stools

  • Trouble sleeping

  • Feeling dizzy

  • Sweating

  • Increased gas

  • Dry mouth

  • Rash

When do I need to call the doctor?

  • Signs of a very bad reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; seizures; swelling of face, lips, tongue, or throat. Go to the ER right away.

  • Very bad throwing up

  • Very bad loose stools

  • Shakiness, feeling nervous, and fast heartbeat

  • Bruising or bleeding that is not normal

  • Changes in menstrual periods like lots of bleeding, spotting, or bleeding between cycles

Where can I learn more?

National Center for Complementary and Integrative Health

https://nccih.nih.gov/health/supplements/SAMe?nav=gsa

Last Reviewed Date

2017-10-13

Consumer information use

This information is not specific medical advice and does not replace information you receive from your healthcare provider. Only your healthcare provider has the knowledge and training to provide advice that is right for you. You should not rely on this information in deciding whether or not to use, or accept your healthcare provider’s advice regarding use of, any natural products or similar treatments, therapies, or life-style choices. This information does not endorse any natural products or similar treatments, therapies, or life-style choices as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information. It does NOT include all information about natural products, possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to you. You must talk with your healthcare provider for complete information about your health and treatment options.

Copyright

Copyright © 2018 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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