Skip to main content


Medically reviewed by Last updated on Aug 7, 2022.

What are other common names?

  • ADE-SD4
  • Ademetionine
  • Adenosylmethionine
  • Adomet
  • S-Adenosyl Methionine
  • S-Adenosyl-L-Methionine
  • S-Adenosylmethionine
  • S-Adenosylmethionine Butanedisulfonate
  • S-Adenosylmethionine Tosylate Disulfate
  • S-Adénosylméthionine
  • SAdenosylmethionine Tosylate
  • SAM
  • SAM-e
  • Samesadenosylmethionine
  • Sammy

What is this product used for?

S-adenosyl-L-methionine is also known as SAMe. It may help with low mood and some forms of arthritis. SAMe may be used to help with itching in people with liver problems.

What are the precautions when taking this product?

  • Always check with your doctor before you use a natural product. Some products may not mix well with drugs or other natural products.

  • Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests.

  • Be sure to tell your doctor if you are pregnant, plan on getting pregnant, or are breastfeeding. You will need to talk about the benefits and risks of using this natural product.

  • Do not take if you have bipolar depression.

  • Do not take this product if you are taking the drug daptomycin or methylene blue. Side effects of this product may be increased.

  • Take extra care if you are taking drugs that effect serotonin, such as some cough medicines, SSRIs, or MAO inhibitors. These are products like St John’s wort, dextromethorphan, fluoxetine, citalopram, isocarboxazid, phenelzine, and tranylcypromine.

  • Take extra care if you are taking levodopa drugs for Parkinson disease.

  • Take extra care and check with your doctor if you have:

    • Mental problems like bipolar disorder or schizophrenia

    • ADHD

    • Low mood

    • Parkinson disease

What should I watch for?

  • Upset stomach

  • Trouble sleeping

  • Feeling dizzy

  • Sweating

When do I need to call the doctor?

  • Signs of a very bad reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; seizures; swelling of face, lips, tongue, or throat. Go to the ER right away.

  • Symptoms of too much serotonin in your body. These include irritability, restlessness, confusion, fast heartbeat, twitching, very bad sweating, very high fever, seizures, or uneven heartbeat.

  • Very bad throwing up

  • Very bad loose or hard stools

Where can I learn more?

National Center for Complementary and Integrative Health

Last Reviewed Date


Consumer information use

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at


Copyright © 2022 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.

More about SAMe (s-adenosylmethionine)

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.