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SAMe User Reviews & Ratings

SAMe has an average rating of 6.6 out of 10 from a total of 9 reviews on 62% of reviewers reported a positive experience, while 31% reported a negative experience.

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Herbal Supplementation  
9 reviews for Herbal Supplementation 25 medications
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Reviews for SAMe

  • Nick
  • July 27, 2017

For Herbal Supplementation "I have been taking SSRIs for 25 years. Still, I have had periods of sadness which increase to an overall sense of lack of interest, eventually leading to seemingly the whole spectrum of depression. I had been taking 400mg/day for a year and didn't notice anything beneficial. Someone (an MD) suggested I might try 1600mg of SAMe along with a Vitamin B supplement. It was incredible that about 3 hours later I suddenly sensed a complete disappearance of sadness. It was absolutely amazing given that these episodes of sadness had plagued me for many years. I will continue to take them for as long as the rest of my life since this one medication suggestion (SAMe and Vit. B complex) has almost single-handedly turned me around."

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  • Nope
  • Taken for 1 to 2 years
  • November 15, 2018

For Herbal Supplementation "Have used SAMe off and on to relieve osteoarthritis pain and to boost activity level secondary to depression. Had severe abdominal pain and nausea after taking one brand of SAMe. Had a similar issue with an OTC medicine to treat the GI disturbance. The common element was mannitol — a sugar alcohol that is present in some supplements and OTC medicines. Read online that this sugar alcohol can trigger severe GI disturbance in some people. I searched for and found a brand of SAMe without mannitol or any other sugar alcohols. There has been no recurrence of GI upset."

8 / 10
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219 Report
  • Wacky...
  • Taken for 5 to 10 years
  • February 23, 2016

For Herbal Supplementation "I've been taking SAM-e for years, heard about it on a PBS special covering depression. It has been mentally beneficial; my moods are much brighter & my behavior is steadier. I don't ever see myself not taking it. There are downsides, however. Anyone considering this medicine must realize that: (1) You cannot be a casual taker; once on it you need to stick with it, because it will make your depression worse if you aren't careful with dosing or wean yourself off of it. (2) It can cause sleeplessness, always take it in the morning (or plan to take a sleep aid in the eve). (3) It is expensive; shop around. (4) You take the enteric-coated on an empty stomach for effectiveness. (5) It takes roughly 3 weeks before relief of symptoms occurs."

9 / 10
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  • Ldrha...
  • May 7, 2021

For Herbal Supplementation "15 years ago I started have knee issues from osteoarthritis. I was a patient at Mayo at the time. The standard pain relievers and injections were prescribed. I bought 200mg SAMe tablets and started taking one a day. I slept through for the first time in a year. I asked my Dr. had he ever heard of SAMe, I asked why didn’t you recommend it. He said I can’t…it’s a supplement and not an FDA approved drug. The osteoarthritis eventually still destroyed my knee joints, but SAMe greatly reduced the pain before they eventually wore out. I refuse to take any of the oxy pain relievers after the knee operations, and simply took Tylenol for a week and SAMe. I have continued to take SAMe daily for last 15 years. I now take 400mgs twice a day. I am 82 and I wouldn’t waste the money if it didn’t living better. I am on no Dr.prescribed medication. Everything on my blood work is normal. I recommend it to people all the time, and they have thanked me after."

10 / 10
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  • GBJ...
  • May 11, 2017

For Herbal Supplementation "I've been taking SAMe for about 2 years, with a brief period of about 2 weeks when I stopped and quickly realized just how much this medication was helping me. I decided to try it due to increasing feelings of sadness and irritation (I have small kids at home and felt like my temper was getting shorter and shorter!). At first, I thought it was helping 'a little' but stopped because of the cost. About a week later, I noticed I was becoming less and less tolerant to small things. When I restarted, the short temper quickly faded and I've stayed on it since."

9 / 10
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Are you taking this medicine?

  • Not...
  • December 2, 2016

For Herbal Supplementation "I took the medicine for 2 days. One pill per day, on the third day I woke up fine, and fifteen minutes later I had severe abdominal pain, sweating enough to drench my shirt and head, disoriented, dizzy, and vomiting. I ended up in the ER and after blood work, an EKG, and a CT scan, they couldn't find anything. They could tell me what it wasn't. They sent me home with anti-nausea medicine. So two days go by and I realize I have not taken my supplement for arthritis, so I take it that afternoon, and by evening, I have severe abdominal pain, dizziness, and vomiting. Pretty sure it was the SAMe because I have felt fine since not taking any."

1 / 10
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  • Happy...
  • Taken for less than 1 month
  • January 26, 2021

For Herbal Supplementation "I’ve had severe depression and anxiety for years and I avoid antidepressants because of the side effects I experienced previously. SAMe has changed me. Since starting it I have felt so stabilized in my mood that I can’t really dwell on the sadness and negative thoughts I used to all day every day. I finally feel normal. However I do feel mildly nauseous throughout the day. This helps me not to eat too much though so it’s not too bad. I does seem to give me the boost I need to get through the day too. I make sure I get my B vitamins in with it. I purchased mine at Walmart."

8 / 10
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  • AlennaM
  • Taken for 1 to 6 months
  • March 24, 2016

"I was shocked how fast this worked. I've been a long-distance runner for years but have gradually gained weight thanks to menopause and occasional binge eating. I had to stop running (or even walking) for 8 months because of an ankle tendon tear and gained even more weight, plus many of my joints became very stiff and achy - especially in the mornings. My ankle finally healed, and I tried to return to simple walking - I was in constant pain when I moved, ankles, knees, lower back. Ibuprofen bothered my stomach. I tried SAMe (a 400mg tablet) and 3 hours later the pain was 80% gone. I've continued it (400mg twice a day) for 2 months now and am walking again. An added benefit - it's helped me lose weight (no more feelings like I want to binge)."

10 / 10
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  • Ukie
  • December 21, 2014

For Osteoarthritis "I like SAMe. It keeps my mood even, and I have arthritis and anxiety. I have had pain remission ever since starting SAMe over 8 months ago. I take it with Super B Complex, which is recommended to keep homocysteine levels even. It works great as a mood elevator. Love it."

10 / 10
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110 Report
  • Chron...
  • March 20, 2021

For Herbal Supplementation "I increased my dose over the course of a month, under the direction of a psychiatric nurse practitioner, to 1600mg. Initially I had nausea, headaches, and anxiety. These symptoms have lessened. The nausea and anxiety make my disordered eating habits (mild anorexia) difficult to manage. I have tracked my depression in a chart daily and my depression has steadily worsened. Last week (during my PMS week) I felt suicidal and afraid of my impulsivity. I have been mostly in bed for two to three weeks, partially due to weather and not having a cozier place to do my schoolwork. Lifestyle changes have given me more hope, like changes to my environment and deciding to get a part time job (I am an online student) to provide more structure and purpose. I am still struggling, however. Weaning myself off SAMe week by week. I don’t think that medication is the answer for me and will focus on making practical changes in my life."

1 / 10
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  • Anonymous
  • February 10, 2011

"I have found SAMe to be superb at relieving the symptoms of depression. I live with chronic severe pain, and even though my pain medicines are very effective, depression was a significant part of my life until I tried SAMe. I can't take any of the tricyclic medicines. I had severe adverse reactions to that whole family of antidepressants, but SAMe works and has no side effects at all. I just feel like me again."

10 / 10
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  • jc1027
  • Taken for less than 1 month
  • September 29, 2021

For Herbal Supplementation "I have moderate depression, mostly seasonal (Seasonal Affective Disorder) but also bouts outside of Winter. I also have moderate GAD (Generalized Anxiety Disorder). I'm a research'o'holic and tried many supplements for various conditions. I started enteric coated SAMe 400mg total at 200mg twice a day (once in morning, once at lunch) for a week. Didn't notice much. I started low to ensure no stomach issues. I read research that the 800mg-1,600mg was most common in studies so upped dose to 400mg twice a day = 800mg. That made the difference. More energy, elevated mood, more motivation, but after about a week on 800mg a day, started to notice I was feeling TOO "up" and started to have moderate anxious feeling, borderline full blown anxiety, all day. Also had consistent negative (aka "bad") dreams. So thanks but no thanks SAMe. Going to switch to Acetyl L-Carnitine (the concerns about TMAO and heart disease have since been debunked in other studies) and see how that goes."

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24 Report
  • lee
  • Taken for less than 1 month
  • April 13, 2023

For Depression "SAMe worked fast to elevate depression, but am worried a placebo effect may be happening in that the speed of this supplement as mentioned by many reviewers! I am not convinced it has a placebo effect as it helps me. I will keep trying it and decide for sure if it is imaginary results we feel or the real thing."

7 / 10
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  • Heywood
  • Taken for 1 to 6 months
  • April 30, 2015

For Osteoarthritis "It works but side effects with digestion so bad Had to stop it."

1 / 10
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54 Report
  • Right...
  • Taken for less than 1 month
  • January 22, 2023

"I took Sam-e for three days and ended up in the emergency room with dizziness so bad I couldn't safely walk, I also felt nauseous and vomited. This medication is not for me."

1 / 10
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12 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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