SAMe Side Effects
Generic name: s-adenosylmethionine
Note: This document contains side effect information about s-adenosylmethionine. Some dosage forms listed on this page may not apply to the brand name SAMe.
Applies to s-adenosylmethionine: oral capsule.
You should not use SAMe if you have bipolar depression, anxiety disorder, or take medicine for depression.
Do not use SAMe if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Although not all side effects are known, SAMe is thought to be likely safe for most adults when used as directed.
Common side effects may include:
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changes in hair color;
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headache, dizziness;
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feeling anxious or nervous;
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loss of appetite, vomiting, nausea, upset stomach;
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dry mouth;
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diarrhea, constipation;
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increased sweating; or
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sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
More about SAMe (s-adenosylmethionine)
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
