Skip to Content

Norvir

Generic Name: ritonavir (rit OH na vir)
Brand Names: Norvir

Medically reviewed on Jul 4, 2018

What is Norvir?

See also: Atripla

Norvir (ritonavir) is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Norvir is used together with other antiviral medicines to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).

Norvir is not a cure for HIV or AIDS.

Important Information

Serious drug interactions can occur when certain medicines are used with Norvir. Tell your doctor about all your current medicines and any you start or stop using.

Taking Norvir will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Before taking this medicine

Serious drug interactions can occur when certain medicines are used with Norvir. Your doctor may need to change your treatment plan if you use any of the following drugs:

Tell your doctor if you have ever had:

Norvir liquid contains alcohol and propylene glycol, and should not be used by pregnant women or premature babies.

Tell your doctor if you become pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Ritonavir can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take Norvir?

Norvir must be given in combination with other antiviral medications and it should not be used alone. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Norvir tablets must be taken with meals. Norvir capsules or liquid should be taken with food if possible.

Swallow the tablet whole and do not crush, chew, or break it.

Shake the oral solution (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Liquid Norvir can be mixed with chocolate milk or a nutrition drink such as Ensure. Drink the mixture within 1 hour after mixing.

Norvir oral powder should be mixed with soft food such as applesauce or pudding. You may also mix the powder with water, chocolate milk, or infant formula.

Follow your doctor's dosing instructions very carefully when giving Norvir to an infant. Tell your doctor when the child has changes in weight or height. Ritonavir doses are based on body surface area in children.

Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

You will need frequent medical tests.

If you've ever had hepatitis B, using Norvir can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.

Store Norvir capsules in the refrigerator or at room temperature, away from heat or moisture. If you store the capsules at room temperature you must use them within 30 days. Protect from light.

Store the tablets, liquid, or powder at room temperature away from heat or moisture. Store the liquid with the cap tightly closed. Do not refrigerate.

Norvir dosing information

Usual Adult Dose for HIV Infection:

Use as a pharmacokinetic (PK) booster for other protease inhibitors: 100 to 400 mg/day orally in 1 or 2 divided doses

Use as an antiretroviral agent (sole protease inhibitor):
-Initial dose: 300 mg orally twice a day; increase by 100 mg twice a day every 2 to 3 days to the full maintenance dose
-Maintenance dose: 600 mg orally twice a day

Comments:
-This drug is most often used and recommended as a PK enhancer of more potent and better tolerated protease inhibitors.
-Use as a PK enhancer for other protease inhibitors is not specifically approved by the US FDA in the manufacturer product information for Norvir.
-The manufacturer product information of the boosted protease inhibitor should be consulted for additional information (including dose recommendations).
-According to experts, this drug should not be used as the sole protease inhibitor for initial therapy.

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Pediatric Dose for HIV Infection:

Use as a PK booster for other protease inhibitors: The manufacturer product information of the boosted protease inhibitor should be consulted for dose recommendations.

Use as an antiretroviral agent (sole protease inhibitor):
Greater than 1 month:
-Initial dose: 250 mg/m2 orally twice a day; increase by 50 mg/m2 twice a day every 2 to 3 days to the full maintenance dose
-Maintenance dose: 350 to 400 mg/m2 orally twice a day
Maximum dose: 600 mg/dose

Comments:
-This drug is most often used and recommended as a PK enhancer of more potent and better tolerated protease inhibitors.
-Use as a PK enhancer for other protease inhibitors is not specifically approved by the US FDA in the manufacturer product information for Norvir.
-If 400 mg/m2 twice a day is intolerable, the highest tolerated dose may be used for maintenance therapy in combination with other antiretrovirals; however, alternative therapy should be considered.
-The oral solution should not be given to neonates before a postmenstrual age of 44 weeks has been reached.
-According to experts, this drug should not be used as the sole protease inhibitor for initial therapy.
-Special attention should be given to accurate calculation of dose, transcription of medication order, dispensing information, and dosing instructions to reduce risk for medication errors and overdose; particularly important for infants and young children.
-Total amounts of alcohol and propylene glycol from all medications (including the oral solution) to be given to pediatric patients 1 to 6 months of age should be considered to avoid toxicity from these excipients.

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of ritonavir oral liquid could be fatal to a child.

What should I avoid while taking Norvir?

Norvir capsules and liquid contain alcohol. Avoid drinking alcoholic beverages while using this medicine, and do not take disulfiram (Antabuse) or you could have an alcohol reaction.

Using Norvir will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Norvir side effects

Get emergency medical help if you have signs of an allergic reaction to Norvir (hives, skin sores, difficult breathing, fast or pounding heartbeats, sweating, mouth sores, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • irregular heartbeats, or a light-headed feeling (like you might pass out);

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor; or

  • signs of liver or pancreas problems - loss of appetite, upper stomach pain (that may spread to your back), nausea, vomiting, dark urine, jaundice (yellowing of the skin or eyes).

Ritonavir affects your immune system, which may cause certain side effects (even weeks or months after you've taken Norvir). Tell your doctor if you have:

  • signs of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common Norvir side effects may include:

  • nausea, vomiting, stomach pain, diarrhea;

  • numbness or tingling in your hands or feet or around your mouth;

  • feeling weak or tired;

  • rash; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Norvir?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with ritonavir, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Norvir only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide