Generic name: zolbetuximab
Brand name: Vyloy
Dosage form: intravenous powder for injection (clzb 100 mg)
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com on Jan 7, 2025. Written by Cerner Multum.

What is zolbetuximab?

Zolbetuximab is used in adults in combination with other cancer treatments to treat cancer of the stomach and gastroesophageal cancer that has spread to other parts of the body (metastatic) or cannot be removed with surgery.

Your doctor will make sure you have the correct tumor type to be treated with zolbetuximab.

Zolbetuximab may also be used for purposes not listed in this medication guide.

Zolbetuximab side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Some side effects may occur during or after the injection with zolbetuximab, including life-threatening allergic reactions and serious infusion-related reactions, which can be fatal.

Call your doctor if you have:

• severe nausea and vomiting.

Common side effects of zolbetuximab may include:

• tiredness;

• loss of appetite and weight loss;

• diarrhea, constipation, stomach pain;

• fever;

• numbness, tingling, or burning pain in your hands or feet; or

• abnormal lab tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use zolbetuximab if you are allergic to it.

Tell your doctor if you have ever had:

• nausea or vomiting.

It is not known if zolbetuximab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using zolbetuximab, and for at least 8 months after your last dose.

How is zolbetuximab given?

Zolbetuximab is injected into a vein by a healthcare provider. This drug is administered every two or three weeks based on chosen chemotherapy combination.

Your healthcare provider will decide how long this drug needs to be administered based on the progress of this treatment.

You will be watched for a short time to make sure you do not have an allergic reaction.

You may be given other medications to help prevent serious side effects or allergic reaction. Keep taking these medicines for as long as your doctor has prescribed.

Zolbetuximab dosing information

Usual Adult Dose for Liver Metastasis in Adenocarcinoma:

First dose: 800 mg/m2 IV infusion
Maintenance dose: 600 mg/m2 IV infusion every 3 weeks or 400 mg/m2 IV infusion every 2 weeks
Duration of therapy: Until disease progression or unacceptable toxicity

Comments:
-Administer antiemetics before each infusion to prevent nausea and vomiting.
-This drug is used in combination with fluoropyrimidine- and platinum-containing chemotherapy.
-The manufacturer product information should be consulted for infusion rates.

Use: For the first-line treatment of patients with locally advanced unresectable or metastatic human epidermal growth factor receptor 2-negative gastric or gastroesophageal junction adenocarcinoma whose tumors are claudin 18.2 positive

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your zolbetuximab injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving zolbetuximab?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect zolbetuximab?

Other drugs may affect zolbetuximab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Zolbetuximab Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for zolbetuximab.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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