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Sodium zirconium cyclosilicate

Generic name: sodium zirconium cyclosilicate ( SOE dee um zir KOE nee um SYE kloe SIL i kate)
Brand name: Lokelma
Dosage forms: oral powder for reconstitution (10 g; 5 g)
Drug class: Cation exchange resins

Medically reviewed by on Sep 21, 2021. Written by Cerner Multum.

What is sodium zirconium cyclosilicate?

Sodium zirconium cyclosilicate is used to treat hyperkalemia (high levels of potassium in the blood) in adults.

Sodium zirconium cyclosilicate works directly in the intestines and is not absorbed into your bloodstream.

Sodium zirconium cyclosilicate may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Tell your doctor if you have ever had:

Because sodium zirconium cyclosilicate is not absorbed into the bloodstream, it is not expected to be harmful during pregnancy or while nursing a baby. Tell your doctor if you are pregnant or breast-feeding.

How should I take sodium zirconium cyclosilicate?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You will need medical tests to help your doctor determine how long to treat you with sodium zirconium cyclosilicate.

Store at room temperature away from moisture and heat.

Sodium zirconium cyclosilicate can make it harder for your body to absorb other medicines you take by mouth. If you take any other medicines, take them 2 hours before or 2 hours after you take sodium zirconium cyclosilicate.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking sodium zirconium cyclosilicate?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Sodium zirconium cyclosilicate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

sodium zirconium cyclosilicate contains sodium and may cause swelling or rapid weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Sodium zirconium cyclosilicate dosing information

Usual Adult Dose for Hyperkalemia:

Initial dose: 10 g orally 3 times a day for up to 48 hours, then 10 g orally once a day
-Dose may be adjusted based on serum potassium level and desired target range; dose may be up-titrated at weekly or greater intervals in 5 g increments
Maintenance dose: 5 g every other day to 15 g once a day

-This drug should not be used for the emergency treatment of life-threatening hyperkalemia because of its delayed onset of action.
-Normal potassium levels are generally achieved within 24 to 48 hours; once normal potassium levels are achieved, the minimal effective maintenance dose should be established.
-Dose should be decreased or discontinued if serum potassium is below the desired target range.

Use: For the treatment of hyperkalemia.

What other drugs will affect sodium zirconium cyclosilicate?

Other drugs may affect sodium zirconium cyclosilicate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does Sodium zirconium cyclosilicate interact with my other drugs?

Enter other medications to view a detailed report.

Frequently asked questions

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.