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Rebif Rebidose

Generic name: interferon beta-1ain-ter-FEAR-on-BAY-ta ]
Brand names: Avonex Pen, Avonex Prefilled Syringe, Rebif, Rebif Rebidose
Drug class: Interferons

Medically reviewed by Drugs.com on Aug 4, 2023. Written by Cerner Multum.

What is Rebif Rebidose?

Rebif Rebidose is used to treat relapsing forms of multiple sclerosis in adults (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease).

Rebif Rebidose will not cure MS, it will only decrease the frequency of relapse symptoms.

Rebif Rebidose may also be used for purposes not listed in this medication guide.

Rebif Rebidose side effects

Get emergency medical help if you have signs of an allergic reaction (hives, itching, anxiety, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Rebif Rebidose can cause life-threatening blood clots in the small blood vessels inside your organs, such as your brain or kidneys. Seek medical help right away if you have symptoms of this condition, such as a fever, tiredness, decreased urination, bruising, or nosebleeds.

Rebif Rebidose may cause serious side effects. Call your doctor at once if you have:

Common side effects of Rebif Rebidose may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Rebif Rebidose can harm your liver. Call your doctor if you have symptoms such as nausea, loss of appetite, tiredness, confusion, easy bruising or bleeding, dark urine, clay-colored stools, or yellowing of your skin or eyes.

Some people have thoughts about suicide while using Rebif Rebidose. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Before taking this medicine

You should not use Rebif Rebidose if you are allergic to natural or recombinant interferon beta or albumin.

Tell your doctor if you have ever had:

Some brands of interferon beta-1a contain donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.

Tell your doctor if you are pregnant or plan to become pregnant, or if you are breastfeeding.

Rebif Rebidose is not approved for use by anyone younger than 18 years old.

How should I use Rebif Rebidose?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Rebif Rebidose is given by injection. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Avonex is injected into a muscle, usually once weekly at bedtime, on the same day each week (such as every Monday).

Rebif is injected under the skin, usually 3 times per week (such as Monday, Wednesday, and Friday) at the same time on each dosing day.

The powder form of this medicine must be mixed with a liquid (diluent) before using it. Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Your care provider will show you where on your body to inject Rebif Rebidose. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

About 2 hours after your injection, check for skin redness, swelling, or pain where you gave the injection. Call your doctor if you have a skin reaction that does not go away within a few days.

This medicine can cause flu-like symptoms, especially when you first start using it. You may be given other medications to help prevent these symptoms. Keep using these medicines for as long as your doctor has prescribed.

You will need frequent medical tests.

Each prefilled syringe or injection pen is for one use only. Throw it away after one use, even if there is still medicine left inside.

Store this medicine in the refrigerator. Protect from light and do not freeze.

After mixing the powder form of interferon beta-1a with a diluent, store the mixture in a refrigerator and use it within 6 hours.

The Avonex prefilled syringe or autoinjector may be removed from the refrigerator about 30 minutes before your injection, to reach room temperature. Do not warm the medicine under hot water.

You may also store Rebif Rebidose for a short time at cool room temperature protected from light.

Do not freeze Rebif Rebidose, and throw away the medicine if it has become frozen.

Each vial, syringe, or autoinjector is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Vumerity, Kesimpta, Copaxone, Tecfidera, Aubagio, Gilenya, Avonex, Tysabri

What happens if I miss a dose?

For Avonex: Use the medicine as soon as you can, but do not inject Avonex two days in a row. Do not use two doses at one time.

For Rebif: Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Rebif Rebidose?

Avoid injecting Rebif Rebidose into skin that is red, bruised, irritated, scarred, or infected.

What other drugs will affect Rebif Rebidose?

Other drugs may affect Rebif Rebidose, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does Rebif Rebidose interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Rebif rebidose Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There are 2 for Rebif Rebidose.

Avonex (interferon beta-1a) - Biogen Inc.
Formulation type Strength
Autoinjector 30 mcg/0.5 mL
Pre-Filled Syringe 30 mcg/0.5 mL
Single-Dose Vial 30 mcg Discontinued

View Avonex information in detail.

Rebif (interferon beta-1a) - EMD Serono, Inc.
Formulation type Strength
Autoinjector 22 mcg/0.5 mL
Autoinjector 44 mcg/0.5 mL
Autoinjector 8.8 mcg/0.2 mL
Pre-Filled Syringe 22 mcg/0.5 mL
Pre-Filled Syringe 44 mcg/0.5 mL
Pre-Filled Syringe 8.8 mcg/0.2 mL

View Rebif information in detail.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.