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Preparation H Maximum Strength

Generic name: glycerin, petrolatum, phenylephrine, and pramoxine topicalGLIS-er-in-PET-roe-LAY-tum-FEN-il-EF-rin-pra-MOX-een-TOP-i-kal ]
Brand names: Preparation H Maximum Strength, Preparation H Multi-Symptom
Drug class: Anorectal preparations

Medically reviewed by on Nov 10, 2023. Written by Cerner Multum.

What is Preparation H Maximum Strength?

Preparation H Maximum Strength is a combination medicine used to relieve pain, soreness, burning, itching, and swelling caused by hemorrhoids.

Preparation H Maximum Strength may also be used for purposes not listed in this medication guide.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Ask a doctor or pharmacist before using this medicine if you are using a medication to treat asthma, COPD, or depression.

Before taking this medicine

Tell your doctor if you have ever had:

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give this medicine to a child younger than 12 years old without medical advice.

How should I use Preparation H Maximum Strength?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take by mouth. This medicine is for use only on the skin around your rectum. Rinse with water if this medicine gets in your eyes or mouth.

You may use this medicine up to 4 times daily, especially after a bowel movement.

Apply the medicine to the skin around the outside of your rectum only. Do not get this medicine inside your rectum.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Call your doctor if your symptoms do not improve after 7 days, or if they get worse.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since Preparation H Maximum Strength is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use more than 4 times per day.

What happens if I overdose?

An overdose of this medicine is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using Preparation H Maximum Strength?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Preparation H Maximum Strength?

Ask a doctor or pharmacist before using Preparation H Maximum Strength with any other medications, especially:

This list is not complete. Other drugs may affect Preparation H Maximum Strength, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about Preparation H Maximum Strength (glycerin / petrolatum / phenylephrine / pramoxine topical)

Patient resources

Other brands

Preparation H Multi-Symptom

Related treatment guides

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.