Generic name: plasminogen (human)
Brand name: Ryplazim
Dosage form: intravenous powder for injection (tvmh 68.8 mg)
Drug class: Miscellaneous uncategorized agents

Medically reviewed by Drugs.com on Feb 11, 2025. Written by Cerner Multum.

What is plasminogen (human)?

Plasminogen (human) is used to increase plasminogen levels in people with plasminogen deficiency type 1 (hypoplasminogenemia).

Plasminogen (human) may also be used for purposes not listed in this medication guide.

Plasminogen (human) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek emergency medical help if you have bloody or tarry stools, vomit blood, or have any heavy bleeding that does not resolve after 30 minutes of direct pressure.

Plasminogen may cause serious side effects. Call your doctor at once if you have:

• problems breathing, wheezing, cough;

• changes in your speech; or

• pelvic area, groin, stomach, or back pain.

Common side effects of plasminogen may include:

• stomach pain, nausea, constipation, bloating;

• joint pain, back pain, pain in your hands or feet;

• tiredness;

• dizziness;

• headache;

• dry mouth; or

• bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use plasminogen (human) if you are allergic to it.

Tell your doctor if you have ever had:

• bleeding problems.

Plasminogen is made from human plasma (part of the blood) which may have viruses that may cause disease. Talk with your doctor about the risks and benefits of using plasminogen.

Tell your doctor if you are pregnant or breastfeeding.

How is plasminogen (human) given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Plasminogen (human) is injected slowly into a vein through an IV over 10 to 30 minutes.

You may receive this medicine at a medical setting, at home from a caregiver, or by injecting it yourself.

Your doctor will tell you how often to use this medicine and how much to use each time.

Your blood may need to be tested often.

Store plasminogen (human) vials at room temperature or in a refrigerator. Do not freeze.

Store other supplies at room temperature.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving plasminogen (human)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect plasminogen (human)?

Other drugs may affect plasminogen (human), including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Plasminogen, human Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for plasminogen, human.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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