Generic Name: palifermin (PAL ee FER min)
Brand Name: Kepivance
What is palifermin?
Palifermin is used to help prevent or heal mouth sores and ulcers in people being treated with chemotherapy and stem cell treatment.
Palifermin is used in people receiving chemotherapy to treat blood cancers (Hodgkin's disease, multiple myeloma, leukemia). palifermin is not a treatment for the cancer itself.
Palifermin may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use palifermin if you are allergic to it.
Palifermin may cause growth in tumors that are not related to a blood cancer. Talk to your doctor if you have a history of any type of tumor.
Palifermin may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
palifermin may affect fertility (your ability to have children), whether you are a man or a woman.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
Palifermin is not approved for use by anyone younger than 1 year old.
How is palifermin given?
Palifermin is given as an infusion into a vein. A healthcare provider will give you this injection before and after your chemotherapy treatment.
Your palifermin injections are timed to take place at certain intervals as part of your treatment. Carefully follow your doctor's instructions about when to receive each injection.
Palifermin should not be given within 24 hours before you receive your chemotherapy.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your palifermin injection.
What happens if I overdose?
Since palifermin is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while using palifermin?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Palifermin side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
blurred vision, tunnel vision, eye pain, or seeing halos around lights.
Common side effects may include:
swelling or redness of your skin;
itching or rash; or
abnormal blood test.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Palifermin dosing information
Usual Adult Dose for Mucositis:
60 mcg/kg IV (as a bolus) once a day, administered for 3 consecutive days before and 3 consecutive days after myelotoxic therapy
-Prior to myelotoxic therapy: The third dose should be administered 24 to 48 hours prior to beginning the myelotoxic agent.
-Following myelotoxic therapy: The first dose should be administered on the day of hematopoietic stem cell infusion after the infusion is complete, AND at least 7 days after the most recent dose of this drug.
-Decrease the incidence and duration of severe oral mucositis in patients with hematologic malignancies receiving myelotoxic therapy in the setting of autologous hematopoietic stem cell support
-Supportive care for preparative regiments predicted to result in greater than or equal to WHO Grade 3 mucositis in the majority of patients
What other drugs will affect palifermin?
Other drugs may affect palifermin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 5.01.
More about palifermin
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: miscellaneous uncategorized agents
Other brands: Kepivance