Generic name: nemolizumab [ NEE-moe-LIZ-ue-mab ]
Brand name: Nemluvio
Dosage form: subcutaneous powder for injection (ilto 30 mg)
Drug class: Interleukin inhibitors

Medically reviewed by Drugs.com on Oct 7, 2024. Written by Cerner Multum.

What is nemolizumab?

Nemolizumab is used in adults to treat prurigo nodularis (a skin condition that causes hard and raised bumps on your skin).

Nemolizumab may also be used for purposes not listed in this medication guide.

Nemolizumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Nemolizumab may cause serious side effects. Call your doctor at once if you have:

• fever;

• skin rash (red or rough skin);

• fainting, feeling light-headed, feeling weak or tired;

• wheezing, trouble breathing;

• fast pulse, swollen glands, nausea or vomiting, stomach cramps; or

• joint pain.

Common side effects of nemolizumab may include:

• headache; or

• skin rash, skin inflammation such as eczema or atopic dermatitis.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use nemolizumab if you are allergic to it.

Tell your doctor if you have or have ever had:

• if you are scheduled to receive a vaccine.

Make sure you are current on all vaccines before you start using nemolizumab.

It is not known if nemolizumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Tell your baby's doctor if you used nemolizumab during pregnancy. It could affect your baby's vaccination schedule during the first 3 months of life.

Ask a doctor if it is safe to breastfeed while using nemolizumab.

How should I take nemolizumab?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Doses are based on weight. Your dose may change if you gain or lose weight.

Nemolizumab is injected under the skin in the stomach, thigh, or upper arm, usually once every 4 weeks. Your first dose may be given in 2 injections to receive the total dose.

A healthcare provider may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Prepare an injection only when you are ready to give it. Leave the needle cap on until you are ready to inject your dose. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it.

Be sure you understand how to properly mix this medicine. Mixed medicine should be kept at room temperature and must be used within 4 hours.

Do not inject within 2 inches of your navel (belly button), or areas where the skin is swollen, tender, bruised, has scars, or has open wounds. Do not inject into the same place two times in a row.

Throw away a pen after one use, even if there is still medicine left inside. Do not reuse a needle, syringe or pen. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Store this medicine in the original container in the refrigerator. Protect from light and do not freeze or shake.

Take the medicine out of the refrigerator and let it reach room temperature for 30 to 45 minutes before injecting your dose. Do not heat the medicine with hot water, sunlight, or a microwave.

You may store this medicine at room temperature for up to 90 days. Throw the medicine away if not used within 90 days. Do not put it back into the refrigerator.

Nemolizumab dosing information

Usual Adult Dose for Prurigo Nodularis:

Patients weighing less than 90 kg: Initial subcutaneous (SC) dose of 60 mg (two 30 mg injections), followed by 30 mg given every 4 weeks
Patients weighing 90 kg or more: Initial SC dose of 60 mg (two 30 mg injections), followed by 60 mg given every 4 weeks:

Comments:
-Complete all age-appropriate vaccinations following immunization guidelines before starting treatment with this drug.

Use: Treatment of adults with prurigo nodularis

What happens if I miss a dose?

Use the medicine as soon as you remember, and then go back to your regular schedule. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using nemolizumab?

Avoid receiving a "live" vaccine while you are being treated or right before starting treatment with nemolizumab. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

What other drugs will affect nemolizumab?

Other drugs may affect nemolizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Nemolizumab Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for nemolizumab.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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