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Generic name: methimazole [ me-THIM-a-zole ]
Brand names: Tapazole, Northyx
Dosage form: oral tablet (10 mg; 5 mg)
Drug class: Antithyroid agents

Medically reviewed by on Aug 14, 2023. Written by Cerner Multum.

What is methimazole?

Methimazole prevents the thyroid gland from producing too much thyroid hormone.

Methimazole is used to treat hyperthyroidism (overactive thyroid). It is also used before thyroid surgery or radioactive iodine treatment.

Methimazole may also be used for purposes not listed in this medication guide.

Methimazole side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious and sometimes fatal infections may occur during treatment with methimazole. Stop using methimazole and call your doctor right away if you have signs of infection such as:

Methimazole may cause serious side effects. Call your doctor at once if you have:

Common side effects of methimazole may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not breast-feed while using this medicine.

Before taking this medicine

You should not use methimazole if you are allergic to it, or:

To make sure methimazole is safe for you, tell your doctor if you have:

Using methimazole during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using methimazole.

Methimazole can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medicine to a child without medical advice.

How should I take methimazole?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Methimazole is usually taken every 8 hours. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times.

If a child is using this medicine, tell your doctor if the child has any changes in weight. Methimazole doses are based on weight in children, and any changes may affect your child's dose.

Methimazole can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.

Use methimazole regularly to get the most benefit, even if you feel fine or have no symptoms of hyperthyroidism. Get your prescription refilled before you run out of medicine completely.

If you need surgery, tell the surgeon ahead of time that you are using methimazole.

Store at room temperature away from moisture and heat.

Methimazole dosing information

Usual Adult Dose for Hyperthyroidism:

Initial dose:
Mild hyperthyroidism: 15 mg orally per day
Moderately severe hyperthyroidism: 30 to 40 mg orally per day
Severe hyperthyroidism: 60 mg orally per day

Maintenance dose:
5 to 15 mg orally per day

Comments: Daily doses are usually given in 3 divided doses at approximately 8 hour intervals

-For the treatment of Graves' disease with hyperthyroidism or toxic multinodular goiter in whom surgery or radioactive iodine therapy is not an appropriate treatment option.
-To ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy.

Usual Pediatric Dose for Hyperthyroidism:

Initial dose: 0.4 mg/kg orally per day

Maintenance dose: 0.2 mg/kg orally per day (approximately half the initial dose)

Comments: Daily doses are usually given in 3 divided doses at approximately 8 hour intervals

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, upset stomach, headache, joint pain, fever, itching, swelling, or pale skin and easy bruising or bleeding.

What should I avoid while taking methimazole?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What other drugs will affect methimazole?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with methimazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Popular FAQ

Yes, hair loss (alopecia) is listed as a side effect of methimazole (brand name: Tapazole) and other thyroid medications. Your hair loss or hair thinning may also be a symptom of hyperthyroidism, when your thyroid gland is overactive and makes too much thyroid hormone. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.