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Lodosyn

Generic name: carbidopa (kar bi DOE pa)
Brand name: Lodosyn
Drug class: Dopaminergic antiparkinsonism agents

Medically reviewed by Drugs.com on Jun 11, 2021. Written by Cerner Multum.

What is Lodosyn?

Lodosyn is used with another medicine called levodopa to treat symptoms of Parkinson's disease, such as stiffness or tremors.

Lodosyn and levodopa are also used to treat Parkinson-like symptoms caused by taking certain medicines or by exposure to poisonous gases or minerals such as carbon monoxide or manganese.

Lodosyn is only used in combination with levodopa and has no effect when used alone.

Lodosyn may also be used for purposes not listed in this medication guide.

Warnings

Do not use Lodosyn if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

Before taking this medicine

You should not use Lodosyn if you are allergic to it, or if you have:

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have ever had:

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for.

It is not known if Lodosyn will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using Lodosyn.

Not approved for use by anyone younger than 18 years old.

How should I take Lodosyn?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

If you already take levodopa but have never taken Lodosyn, start taking both medicines at least 12 hours after you last took levodopa by itself.

Take both Lodosyn and levodopa together at regular intervals, to keep steady amounts in your body at all times.

You may need frequent medical tests.

Your symptoms may not improve for several weeks. Call your doctor if your symptoms do not improve or if the effects of Lodosyn wear off quickly between doses.

You may have withdrawal symptoms if you stop using Lodosyn suddenly. Ask your doctor before stopping the medicine.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Lodosyn.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lodosyn?

Avoid driving or hazardous activity until you know how Lodosyn will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid taking iron supplements or eating a diet high in protein. These things can make it harder for your body to digest and absorb Lodosyn and levodopa. Talk with your doctor or dietitian about the best foods to eat or avoid.

Lodosyn side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

The following side effects may occur when Lodosyn is taken with levodopa.

Call your doctor at once if you have:

  • severe drowsiness;

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

  • worsening of tremors (uncontrolled shaking);

  • severe nausea, vomiting, or diarrhea;

  • confusion, hallucinations, unusual changes in mood or behavior;

  • depression or suicidal thoughts;

  • seizure (convulsions); or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Some people taking Lodosyn with levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lodosyn?

Using Lodosyn with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect Lodosyn, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Does Lodosyn interact with my other drugs?

Enter other medications to view a detailed report.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.