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Crizotinib

Generic Name: crizotinib (kriz OH ti nib)
Brand Name: Xalkori

Medically reviewed by Drugs.com on Jan 3, 2019 – Written by Cerner Multum

What is crizotinib?

See also: Alunbrig

Crizotinib is used to treat non-small cell lung cancer that has spread to other parts of the body.

Crizotinib may also be used for purposes not listed in this medication guide.

Important Information

Crizotinib can cause serious heart or liver problems. Call your doctor at once if you have: fast or pounding heartbeats, sudden dizziness, shortness of breath, upper stomach pain, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Before taking this medicine

You should not use crizotinib if you are allergic to it.

Tell your doctor if you have ever had:

  • liver or kidney disease;

  • a heart rhythm disorder;

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

  • long QT syndrome (in you or a family member); or

  • if you take any heart or blood pressure medicines.

Crizotinib can harm an unborn baby or cause birth defects if the mother or the father is using crizotinib.

  • If you are a woman, do not use crizotinib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 45 days after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 90 days after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using crizotinib.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because crizotinib can harm an unborn baby.

You should not breast-feed while you are using crizotinib.

How should I take crizotinib?

Before you start treatment, your doctor may perform tests to make sure crizotinib is the best treatment for your type of lung cancer.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Crizotinib is usually taken twice per day, with or without food.

Swallow the capsule whole and do not crush, chew, break, or open it.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

You should not stop taking crizotinib without your doctor's advice.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 6 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking crizotinib?

Grapefruit may interact with crizotinib and lead to unwanted side effects. Avoid the use of grapefruit products.

crizotinib may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Crizotinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe vision problems, including loss of vision;

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

  • very slow heartbeats;

  • a light-headed feeling, like you might pass out;

  • sudden chest pain or discomfort, wheezing, dry cough or cough with mucus, feeling short of breath;

  • fever, swollen gums, painful mouth sores, pain when swallowing, cold or flu symptoms;

  • easy bruising or bleeding (nosebleeds, bleeding gums); or

  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Crizotinib dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

250 mg orally twice a day until disease progression or unacceptable toxicity

Use: For the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK) or ROS1-positive as detected by an FDA-approved test.

What other drugs will affect crizotinib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect crizotinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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