Generic Name: chenodiol (chenodeoxycholic acid) (KEE noe DYE ol (KEE noe dee OX i KOL ik AS id))
Brand Name: Chenodal
What is Chenodal (chenodiol)?
Chenodiol is made from bile acid, a substance that occurs naturally in the body.
Chenodiol is used to dissolve gallstones in people who cannot have gallbladder surgery.
Chenodiol may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Chenodal (chenodiol)?
Chenodiol can harm an unborn baby or cause birth defects. Do not use if you are pregnant.
You should not use chenodiol if you are allergic to it, or if you have liver disease, cirrhosis, or certain conditions that cause an obstruction in your digestive system.
Before you take chenodiol, tell your doctor if you have a history of liver problems or jaundice.
While using chenodiol, you will need frequent medical tests at your doctor's office. Visit your doctor regularly.
Chenodiol is only part of a complete program of treatment that may also include weight control and a special diet. Follow the diet plan created for you by your doctor or nutrition counselor.
Use chenodiol regularly to get the most benefit. It may take up to 12 months before your symptoms improve. Chenodiol is usually given for no longer than 2 years.
Even with treatment, there is a chance that your gallstones may return within 5 years. Chenodiol will not prevent gallstones from occurring.
What should I discuss with my healthcare provider before taking Chenodal (chenodiol)?
You should not use chenodiol if you are allergic to it, if you are pregnant, or if you have liver disease, cirrhosis, or certain conditions that cause an obstruction in your digestive system.
To make sure you can safely use chenodiol, tell your doctor if you have a history of liver problems or jaundice.
'FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use chenodiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medication.
It is not known whether chenodiol passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take Chenodal (chenodiol)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Chenodiol is usually taken 2 times each day until your gallstones are completely dissolved. Follow your doctor's instructions.
Chenodiol is usually given for no longer than 2 years.
Use chenodiol regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
It may take up to 12 months before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 6 months of treatment.
To be sure this medication is not causing harmful effects, your liver function will need to be checked with frequent blood tests. You may also need an occasional ultrasound or x-ray examination of your gallbladder. Visit your doctor regularly.
Chenodiol is only part of a complete program of treatment that may also include weight control and a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must avoid to help control your condition.
Even with treatment, there is a chance that your gallstones may return within 5 years. Talk to your doctor about your specific risk. Chenodiol will not prevent gallstones from occurring.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Chenodal (chenodiol)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity. Avoid eating foods that are high in fat or cholesterol.
Chenodal (chenodiol) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using chenodiol and call your doctor at once if you have a serious side effect such as:
worsening or no improvement of your gallstone symptoms;
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
heartburn, upset stomach, gas;
mild stomach cramps; or
vomiting, loss of appetite.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Chenodal (chenodiol)?
Tell your doctor about all other medicines you use, especially:
a blood thinner such as warfarin (Coumadin, Jantoven);
cholestyramine (Prevalite, Questran) or colestipol (Colestid);
birth control pills or hormone replacement therapy; or
antacids that contain aluminum (such as Acid Gone, Aldroxicon, Alternagel, Di-Gel, Gaviscon, Gelusil, Maalox, Maldroxal, Mylagen, Mylanta, Rulox, and others).
This list is not complete and other drugs may interact with chenodiol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More about Chenodal (chenodeoxycholic acid)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about chenodiol.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 1.02.
Date modified: January 10, 2017
Last reviewed: December 03, 2013