Generic Name: chenodiol (chenodeoxycholic acid) (KEE noe DYE ol (KEE noe dee OX i KOL ik AS id))
Brand Name: Chenodal
What is chenodiol?
Chenodiol is made from bile acid, a substance that occurs naturally in the body.
Chenodiol may also be used for purposes not listed in this medication guide.
You should not use this medicine if you have liver disease, cirrhosis, or certain conditions that cause an obstruction in your digestive system.
Chenodiol can harm an unborn baby or cause birth defects. Do not use if you are pregnant.
Before taking this medicine
You should not use chenodiol if you are allergic to it, or if:
you are pregnant;
you have a bile duct obstruction or other disorder;
you have pancreatitis related to your gallstones;
you have cirrhosis or other liver disease; or
you have a blockage in your digestive tract (stomach or intestines).
To make sure chenodiol is safe for you, tell your doctor if you have a history of liver problems or jaundice.
Do not use chenodiol if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine.
It is not known whether chenodiol passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How should I take chenodiol?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Chenodiol is usually taken 2 times each day until your gallstones are completely dissolved. Follow your doctor's instructions.
Chenodiol is usually given for no longer than 2 years.
Use chenodiol regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
It may take up to 12 months before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 6 months of treatment.
While using chenodiol, you may need frequent blood tests. You may also need an occasional ultrasound or x-ray examination of your gallbladder.
Chenodiol is only part of a complete program of treatment that may also include weight control and a special diet. Follow the diet plan created for you by your doctor or nutrition counselor. Get familiar with the list of foods you must avoid to help control your condition.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Even with treatment, there is a chance that your gallstones may return within 5 years. Talk to your doctor about your specific risk. Chenodiol will not prevent gallstones from occurring.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking chenodiol?
Follow your doctor's instructions about any restrictions on food, beverages, or activity. Avoid eating foods that are high in fat or cholesterol.
Chenodiol side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
worsening or no improvement of your gallstone symptoms;
severe or ongoing diarrhea; or
liver problems--loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
mild stomach cramps; or
abnormal blood tests (low white blood cells, high cholesterol or triglycerides).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Chenodiol dosing information
Usual Adult Dose for Gallbladder Disease:
For patients with radiolucent stones in well opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age:
13 to 16 mg/kg/day in two divided doses, morning and night, starting with 250 mg twice a day for the first two weeks and increasing by 250 mg/day each week thereafter until the recommended or maximum tolerated dose is reached. If diarrhea occurs during dosage buildup or later in treatment, it usually can be controlled by temporary dosage adjustment until symptoms abate, after which the previous dosage usually is tolerated. Dosage less than 10 mg/kg usually is ineffective and may be associated with increased risk of cholecystectomy, so is not recommended. Safety of use beyond 24 months is not established.
What other drugs will affect chenodiol?
Tell your doctor about all your current medicines and any you start or stop using, especially:
birth control pills or hormone replacement therapy;
This list is not complete. Other drugs may interact with chenodiol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about chenodeoxycholic acid
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: gallstone solubilizing agents
Other brands: Chenodal
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about chenodiol.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 1.03.
Date modified: January 03, 2018
Last reviewed: April 16, 2017