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Advil Cold & Sinus

Generic name: ibuprofen and pseudoephedrine (EYE bue pro fen and SOO doe ee FED rin)
Brand name: Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel
Drug class: Upper respiratory combinations

Medically reviewed by Drugs.com on Jun 14, 2021. Written by Cerner Multum.

What is Advil Cold & Sinus?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Pseudoephedrine is a decongestant.

Advil Cold & Sinus is a combination medicine used to treat stuffy nose, sinus congestion, cough, and pain or fever caused by the common cold or flu.

Advil Cold & Sinus may also be used for purposes not listed in this medication guide.

Warnings

Ibuprofen can increase your risk of fatal heart attack or stroke. Do not use Advil Cold & Sinus just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal.

Before taking this medicine

Ibuprofen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Advil Cold & Sinus, especially in older adults.

You should not use this medicine if you are allergic to ibuprofen or pseudoephedrine, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Do not use Advil Cold & Sinus if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Do not give ibuprofen to a child younger than 12 years old.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

If you are pregnant, you should not take Advil Cold & Sinus unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

Ask a doctor before using this medicine if you are breastfeeding.

How should I take Advil Cold & Sinus?

Use exactly as directed on the label, or as prescribed by your doctor. An overdose of ibuprofen can damage your stomach or intestines.

Take Advil Cold & Sinus with food or milk to lessen stomach upset.

Call your doctor if you have a fever lasting longer than 3 days, if you have new symptoms, or if your condition does not improve after taking this medication for 7 days.

If you need surgery, tell the surgeon ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, stomach pain, diarrhea, ringing in your ears, severe drowsiness, agitation, sweating, coughing up blood, weak or shallow breathing, fainting, or seizure (convulsions).

What should I avoid while taking Advil Cold & Sinus?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Ask a doctor or pharmacist before using other cough or cold medicines that may contain similar ingredients.

Advil Cold & Sinus side effects

Get emergency medical help if you have signs of an allergic reaction (sneezing, runny or stuffy nose, hives, wheezing or trouble breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.

Stop using Advil Cold & Sinus and call your doctor at once if you have:

  • confusion, severe drowsiness, ringing in your ears, severe dizziness, feeling like you might pass out;

  • fast, pounding, or uneven heartbeat;

  • easy bruising or bleeding (nosebleeds, bleeding gums);

  • a skin rash, no matter how mild;

  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

  • nerve problems--fever, headache, neck stiffness, chills, increased sensitivity to light, seizure (convulsions).

Common side effects may include:

  • diarrhea, constipation;

  • headache, dizziness, drowsiness, weakness;

  • upset stomach, nausea, vomiting, loss of appetite;

  • feeling anxious or excited;

  • sleep problems (insomnia); or

  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Advil Cold & Sinus?

Ask your doctor before using Advil Cold & Sinus if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist before using Advil Cold & Sinus with any other medications, especially:

This list is not complete. Other drugs may affect Advil Cold & Sinus, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does Advil Cold and Sinus interact with my other drugs?

Enter other medications to view a detailed report.

More about Advil Cold and Sinus (ibuprofen / pseudoephedrine)

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.