Zepbound Vs Mounjaro: Complete Comparison Guide for Weight Loss and Diabetes Treatment
Zepbound and Mounjaro both contain tirzepatide and are both made by Eli Lilly and Company. The key difference lies in their FDA-approved uses and branding strategy.
The key considerations when choosing between Mounjaro and Zepbound are:
- Primary health concern (diabetes vs weight management vs obstructive sleep apnea [OSA])
- Insurance coverage, copay assistance program eligibility, and cost differences
- Healthcare provider recommendation
- Individual insurance plan policies
- Prior authorization requirements.
FDA-Approved Uses
Mounjaro
Primary indication: Treatment of type 2 diabetes in adults
- Used alongside diet and exercise.
- Helps improve blood sugar control.
Zepbound
Primary indication 1: Chronic weight management in adults
- For patients with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related condition.
- Used in combination with reduced-calorie diet and increased physical activity.
Primary indication 2: Obstructive sleep apnea (OSA) in adults
- For patients with moderate to severe obesity.
Brand strategy
Eli Lilly intentionally created two separate brands for tirzepatide and the dual branding strategy serves several purposes:
- Allows for different insurance coverage pathways
- Helps healthcare providers prescribe for specific conditions
- Enables targeted marketing for different patient populations
- Complies with FDA labeling requirements for different indications.
Dosing and Administration
Both medications:
- Are administered via subcutaneous (under the skin) injection 1 time a week
- Are available in the same dose strengths: 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, 15mg
- Follow identical dose escalation schedules
- Use the same injection pen design and technology.
Clinical Trial Results
Weight Loss Effectiveness
- Both Zepbound and Mounjaro have demonstrated significant weight loss in clinical trials
- Average weight loss at 15mg dose: 20.9% of body weight over 72 weeks
- Placebo comparison: 3.1% weight loss in the same time period.
Blood Sugar Control
- Both medications improve blood sugar levels.
- Blood sugar control has particularly been studied in Mounjaro trials for type 2 diabetes and it showed significant hemoglobin A1C reduction compared to placebo.
Cost and Insurance Coverage
Insurance coverage varies based on intended use:
- Mounjaro: Often covered under diabetes treatment benefits.
- Zepbound: May be covered under weight management benefits but not clear if it will be covered for OSA.
- Different insurance requirements and prior authorization processes.
Related questions
- Ozempic Side Effects to Watch For
- Why am I not losing weight on Mounjaro?
- How do Ozempic, Mounjaro, Wegovy, Zepbound compare for weight loss?
Side Effects and Safety Profile
Common side effects for both Zepbound and Mounjaro include:
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Stomach pain
- Decreased appetite.
Important Safety Information
- Not recommended for type 1 diabetes
- Caution in patients with history of pancreatitis
- Regular monitoring recommended during treatment
FAQs about Zepbound vs Mounjaro
Is Mounjaro the same as Zepbound?
Yes and no. Mounjaro and Zepbound contain exactly the same active ingredient (tirzepatide) and are identical medications molecularly. However, they have different FDA approvals and are marketed for different purposes:
- Mounjaro: FDA-approved for type 2 diabetes
- Zepbound: FDA-approved for chronic weight management.
Which is better for weight loss: Mounjaro or Zepbound?
Neither is "better" as they contain the identical active ingredient (tirzepatide) and work exactly the same way in the body. The clinical trials showing 20.9% average weight loss apply to both medications. The choice between them typically depends on:
- Primary medical condition (diabetes vs weight management)
- Insurance coverage
- Cost considerations
- Healthcare provider preference.
Can Mounjaro and Zepbound be used together?
No, Mounjaro and Zepbound should never be used together because:
- They are the exact same medication (tirzepatide)
- Using both would result in double-dosing
- This could lead to serious side effects
- No additional benefits would be gained.
How do insurance companies cover Mounjaro vs Zepbound?
Mounjaro coverage:
- Generally covered under diabetes medication benefits
- May require proof of type 2 diabetes diagnosis
- Might need documentation of previous diabetes medication use
- Often requires prior authorization.
Zepbound coverage:
- Typically falls under weight management benefits
- May require specific BMI criteria
- Could need documentation of previous weight loss attempts
- Many insurance plans exclude weight loss medications
- Not clear if insurance companies will cover for OSA
- May require different prior authorization process.
References
- Mounjaro Prescribing Information. https://uspl.lilly.com/mounjaro/mounjaro.html#pi
- Zepbound Prescribing Information. https://uspl.lilly.com/zepbound/zepbound.html#pi
Read next
How much is Zepbound with or without insurance?
Zepbound may cost $25 if you have insurance, or without insurance, Zepbound can cost $349 for a 2.5mg vial and $499 for a 5mg vial Continue reading
How long does it take for Zepbound to work?
In clinical studies submitted to the FDA for approval, patients lost weight during the first 4 weeks of taking Zepbound (tirzepatide). How quickly you lose weight on Zepbound depends on various factors, including your starting weight, the dose you’re taking, diet, and physical activity level. Continue reading
Can you get tirzepatide from a compounding pharmacy?
Some pharmacies or clinics may supply compounded versions of medicines like tirzepatide (Mounjaro, Zepbound) and semaglutide (Ozempic, Wegovy) to patients, but the FDA has issued safety warnings about this practice. Concerns have risen over active ingredients, side effects and labeling of these compounded products. Continue reading
Related medical questions
- How do Zepbound and Wegovy compare?
- Is Zepbound covered by insurance?
- How much weight can I lose on Zepbound?
- What happens when you stop taking Zepbound?
- How does Zepbound help treat sleep apnea?
- How do I know if I have sleep apnea? The warning signs
- How do you inject / administer Zepbound?
- What is the Zepbound Coupon or Savings Card?
- Can Zepbound and Mounjaro be used for heart failure?
- Mounjaro vs Ozempic: Which is right for you?
- Do Ozempic, Wegovy, Mounjaro & Zepbound cause hair loss?
- How long does it take for Mounjaro to start working?
- Can you switch between Ozempic and Mounjaro?
- Is Mounjaro covered by insurance or Medicare?
- Mounjaro constipation: Why it happens and how to get relief?
- Do you gain weight back after stopping Mounjaro?
- Does Mounjaro need to be refrigerated?
- Where is the best place to inject Mounjaro?
- Do GLP-1 drugs like Ozempic and Mounjaro cause sulfur burps?
- If Mounjaro has no diet plan, what food should you eat?
- Does Mounjaro cause blurry vision?
- Does Mounjaro cause fatigue?
- Why does Mounjaro require a gradual increase in dosage?
- What is the Mounjaro Coupon or Savings Card?
- Does the Mounjaro injection hurt?
- Can I take antibiotics with Mounjaro?
- Trulicity vs Mounjaro: How do they compare?
- What options are there for weight loss medications?
Drug information
Related support groups
- Zepbound (19 questions, 24 members)
- Mounjaro (49 questions, 121 members)
- Tirzepatide (15 questions, 13 members)
- Diabetes, Type 2 (500 questions, 1,426 members)
- Weight Loss (Obesity/Overweight) (848 questions, 1,508 members)
- Obstructive Sleep Apnea/Hypopnea Syndrome (27 questions, 56 members)