Can you use Winlevi and tretinoin together?

Yes, it’s possible to use Winlevi and tretinoin together if your dermatologist has prescribed them both. However, both medications can cause skin irritation, so ask your doctor if you should be alternating or spacing them out a certain way.

Winlevi (clascoterone) and tretinoin topical are both topical (for the skin) prescription medications used to treat acne. They work in different ways. Some people might benefit from using the combination if one product alone isn’t working well enough.

How do Winlevi and tretinoin work to treat acne?

Winlevi blocks hormones in the skin that are called androgens. This lessens the production of an oily substance in your skin that can cause acne. The exact way Winlevi works to treat acne isn’t known.

Tretinoin is made from vitamin A. It’s thought to treat acne by unclogging pores and removing the skin cells that form pimples.

When should Winlevi and tretinoin be applied?

Winlevi is applied twice a day, in the morning and evening. If your dermatologist prescribes it together with tretinoin, they might recommend taking it differently to avoid skin irritation.

Tretinoin is typically applied once daily before bedtime. Your dermatologist might recommend that you apply it every other night if your skin is sensitive.

If you’re using both products at the same time, wait until the first dries before using the next. This gives the medication a chance to get fully absorbed into your skin.

It might be helpful to layer the two products in a certain way. Winlevi is only available as a cream, so if you’re also using tretinoin cream, the order likely won’t matter. However, if you’re using tretinoin gel or lotion, it might be quicker to apply these first. They are lighter than creams and will dry faster on your skin.

What are Winlevi side effects?

Common side effects associated with using Winlevi include:

• Red skin
• Dry skin
• Stinging or burning skin
• Swelling
• Itchy skin

It’s best to avoid applying Winlevi to skin that’s damaged or sunburned, since these areas are more sensitive to irritation.

What are tretinoin side effects?

Some side effects associated with using tretinoin include:

• Red skin
• Blisters
• Swelling
• Changes in skin color
• Temporary stinging
• Sensitivity to sunlight

Not everyone will experience side effects from tretinoin. If you do have skin irritation, it can take 2 to 4 weeks for your skin to adjust. Tell your doctor if the irritation is too bothersome, because they might be able to adjust your dosage.

Bottom Line

Winlevi and tretinoin are both topical medications used to treat acne. They work differently, and could potentially be used together.

Both Winlevi and tretinoin can cause skin irritation such as redness, stinging, and swelling. Using them together might make these side effects worse.

If you’ve been prescribed both Winlevi and tretinoin, ask your dermatologist about how to use them together safely.