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Can you take Ozempic after gallbladder removal?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on March 18, 2025.

Official Answer by Drugs.com

There is limited data on using Ozempic (semaglutide) in people without a gallbladder. While you may be able to resume Ozempic after surgery, your healthcare provider will determine the appropriate timing and dosage based on your recovery.

Some people experience diarrhea and gas after gallbladder removal, which are also common side effects of Ozempic. Your provider may suggest waiting until these symptoms improve before restarting Ozempic to avoid worsening digestive discomfort.

Should You Stop Ozempic Before Gallbladder Surgery?

If you are taking Ozempic, consult your healthcare provider about whether you need to pause treatment before surgery. Some patients at high risk for pulmonary aspiration (when food or liquid enters the lungs) may need to stop Ozempic about a week before procedures requiring anesthesia or sedation.

When Can You Restart Ozempic After Surgery?

Your healthcare team will inform you when it is safe to restart Ozempic or begin any new medications. The timeline may depend on:

If you go home the same day, a caregiver should stay with you until the anesthesia fully wears off. Your healthcare provider will give you specific instructions on resuming medications once you are home.

Related questions

Managing Side Effects After Gallbladder Removal

It is normal to experience digestive changes such as diarrhea and gas after gallbladder surgery. These symptoms are similar to potential side effects of Ozempic. Your healthcare provider can help determine whether your symptoms are surgery-related or medication-related. In some cases, they may recommend:

This is not all the information you need to know about Ozempic (semaglutide) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

American Gastroenterological Association. 2024. Multisociety Clinical Practice Guidance for the Safe Use of Glucagon-like Peptide-1 Receptor Agonists in the Perioperative Period. Accessed 12/04/2024 at https://www.cghjournal.org/article/S1542-3565(24)00910-8/fulltext

National Health Service. 2021. Gallbladder removal. Accessed 12/04/2024 at https://www.nhs.uk/conditions/gallbladder-removal/recovery/

Ozempic [package insert]. Updated November 2024. Novo Nordisk. Accessed 11/20/2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79

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