Do you gain weight back after stopping Mounjaro?

Key Points

• Mounjaro (tirzepatide) is a once-weekly injectable medication used alongside diet and exercise to treat type 2 diabetes.
• Weight loss is a common side effect, with clinical studies showing up to 7.8 kg (17.1 lb) lost in 40 weeks.
• Weight regain is likely after stopping Mounjaro.
• Mounjaro is not FDA-approved for weight loss; however, its active ingredient, tirzepatide, is approved for weight management under the brand name Zepbound.

What is Mounjaro?

Mounjaro (tirzepatide), is an FDA-approved injectable medication for type 2 diabetes. It is prescribed in combination with diet and exercise to improve blood sugar control. While not officially a weight loss drug, weight loss is a common side effect. In clinical trials, participants lost up to 7.8 kg (17.1 lb) over 40 weeks.

How Much Weight Do You Gain Back After Stopping Mounjaro?

There is limited research on weight regain after stopping Mounjaro for type 2 diabetes. However, a study on tirzepatide (the active ingredient) in adults without diabetes found that participants regained about 14% of their lost weight within a year after stopping treatment. This was an average weight gain of 11.1 kg (24.5 lb).

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Why Does Weight Regain Occur After Stopping Mounjaro?

Mounjaro works by increasing GLP-1 and GIP hormone levels, which help regulate appetite and food intake. When the medication is discontinued, these hormone levels decrease, leading to increased hunger and potential weight gain.

Lifestyle factors also contribute to weight regain. Returning to previous eating habits or reducing physical activity can further impact weight maintenance.

How to Maintain Weight Loss After Stopping Mounjaro

To help sustain weight loss after discontinuing Mounjaro, consider the following strategies:

• Maintain a balanced diet rich in fiber, protein, and healthy fats.
• Exercise regularly to support metabolism and muscle retention.
• Seek medical guidance from a healthcare provider for personalized weight management strategies.

If you notice significant weight regain after stopping Mounjaro, consult your doctor. They can help develop a plan to maintain a healthy weight and prevent further weight gain.

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Drug information

• Mounjaro Information for Consumers
• Mounjaro prescribing info & package insert (for Health Professionals)
• Side Effects of Mounjaro (detailed)
• Mounjaro user reviews (1,375)

Related support groups

• Mounjaro (51 questions, 122 members)
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