Is Trintellix an SSRI drug?
No, Trintellix is not classified as a selective serotonin reuptake inhibitor (SSRI). While it does increase serotonin levels in the brain by blocking its reuptake—similar to how SSRIs work—Trintellix has a broader mechanism of action that involves modulating several serotonin receptors. This pharmacological profile sets it apart from traditional SSRIs such as sertraline (Zoloft) or fluoxetine (Prozac).
How SSRIs and Trintellix Differ in Action
SSRIs are among the most well-known classes of antidepressants. They work by selectively inhibiting the serotonin transporter on presynaptic neurons, which leads to increased levels of serotonin—a neurotransmitter involved in mood regulation—in the synaptic gap. The drugs in this class (like sertraline, fluoxetine, escitalopram) do not significantly affect other neurotransmitter systems and act almost exclusively on serotonin reuptake.
Trintellix (generic name: vortioxetine), although it does block serotonin reuptake, has a distinctive mechanism: it interacts with multiple serotonin receptors. Specifically, Trintellix is a 5-HT₁A receptor agonist (stimulates this receptor), a 5-HT₁B partial agonist, a 5-HT₁D, 5-HT₃, and 5-HT₇ receptor antagonist (blocks these receptors), in addition to its serotonin reuptake inhibition. This blend of actions has led the FDA and medical publications to classify Trintellix as a “serotonin modulator and stimulator,” not as an SSRI.
Clinical Implications of Trintellix’s Mechanism
One consequence of Trintellix’s multimodal action is the potential for additional clinical benefits compared to traditional SSRIs. For instance, research suggests that Trintellix may have pro-cognitive effects, which could be particularly beneficial for adults with depression who experience cognitive impairment.
Additionally, clinical studies have indicated that Trintellix might cause fewer sexual side effects than certain SSRIs, an issue that often limits the use of more traditional antidepressants. However, sexual side effects are still possible and are dose-dependent.
Common Confusion about Trintellix and SSRIs
Many people (including patients and sometimes healthcare professionals) are confused about whether Trintellix is an SSRI because both types of drugs increase serotonin activity and treat similar conditions, especially major depressive disorder. This confusion is understandable, given the overlap in effects and the SSRI-like component of Trintellix’s action. However, the FDA officially classifies Trintellix as a serotonin modulator and stimulator rather than an SSRI. This distinction reflects its broader effects on multiple serotonin receptors, rather than solely blocking serotonin reuptake.
Conclusion
In summary, Trintellix is a unique antidepressant with a broader action profile than traditional SSRIs. While it increases serotonin levels (like SSRIs), its innovative modulation of several serotonin receptors sets it apart and gives it an official classification as a serotonin modulator and stimulator, not an SSRI.
This is not all the information you need to know about Trintellix for safe and effective use and does not take the place of your doctor’s directions. Review the full patient medication guide and discuss this information and any questions you have with your doctor or other health care provider.
References
- American Society of Health-System Pharmacists, Inc. (2022, January 15). Vortioxetine: MedlinePlus Drug Information. MedlinePlus. Accessed on August 7, 2025 at https://medlineplus.gov/druginfo/meds/a614003.html
- Bennabi, D., Haffen, E., & Van Waes, V. (2019). Vortioxetine for Cognitive Enhancement in Major Depression: From Animal Models to Clinical Research. Frontiers in psychiatry, 10, 771. https://doi.org/10.3389/fpsyt.2019.00771
- Elsevier Health. 2024. Selective Serotonin Reuptake Inhibitors (SSRIs). In: Mental and Behavioral Health. Accessed on August 7, 2025 at https://elsevier.health/en-US/preview/selective-serotonin-reuptake-inhibitors-ssris
- Trintellix [package insert]. Updated March 2025. Takeda Pharmaceuticals America, Inc. Accessed on August 7, 2025 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a5b68e2-14d0-419d-9ec6-1ca97145e838
Read next
How long does Trintellix withdrawal last?
Trintellix (vortioxetine) withdrawal symptoms can last for 2 weeks or longer. Withdrawal symptoms can appear within a few days after discontinuing Trintellix. Gradually tapering down your dose under your healthcare provider's supervision can help lower your risk of withdrawal symptoms. Continue reading
Can Trintellix be split or cut in half?
No, Trintellix tablets should not be cut in half. They are film-coated and specifically designed to be taken whole.
Continue reading
Does Trintellix cause sexual side effects?
Yes, Trintellix (vortioxetine) can cause sexual side effects in males and females. This is common when taking antidepressants that affect serotonin like Trintellix. Sexual side effects reported in patients taking Trintellix include low sex drive and difficulty achieving an orgasm. Continue reading
See also:
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Drug information
- Trintellix Information for Consumers
- Trintellix prescribing info & package insert (for Health Professionals)
- Side Effects of Trintellix (detailed)
- Trintellix user reviews (1,135)
Related support groups
- Trintellix (82 questions, 192 members)