Can Trintellix be split or cut in half?
No, Trintellix tablets should not be cut in half. They are film-coated and specifically designed to be taken whole to ensure you receive the accurate dose and proper absorption of the medication.
Why Splitting Trintellix Tablets Is Not Recommended
Trintellix (also known as vortioxetine) tablets have a film coating that serves several important purposes:
- Protects the drug’s integrity: The coating helps shield the active ingredient from moisture, light, and stomach acid, ensuring the medication remains effective until it reaches the right part of your digestive system.
- Ensures consistent absorption: Splitting the tablet can damage this coating, potentially leading to uneven or unpredictable absorption of the medication.
- Prevents dosing errors: Cutting a tablet that is not scored in half may result in unequal pieces, making it difficult to receive the precise dose prescribed by your doctor. This could reduce the effectiveness of the treatment or increase the risk of side effects.
What If the Prescribed Dose Isn’t Available?
If your prescribed dose is not available, you should not attempt to split or cut Trintellix tablets.
Trintellix is available in several strengths, such as 5 mg, 10 mg, and 20 mg, to suit different dosing needs. If your required dose isn’t readily available, speak to your doctor or pharmacist. They can prescribe the correct strength or offer alternative solutions based on your treatment plan.
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Manufacturer and FDA Guidance
Official prescribing information and the FDA-approved label for Trintellix do not support splitting or crushing the tablets. The FDA-approved medication guide can be found on resources like Drugs.com or the official FDA website.
Safe Medication Practices
- Always follow your prescription instructions exactly.
- If you have trouble swallowing pills, talk to your pharmacist or healthcare provider. They may be able to recommend safe alternatives, such as a different formulation or a smaller strength tablet that is easier to swallow.
- Never alter how you take your medication without consulting your prescriber, as even small changes can affect how well the drug works and its side effect risk.
Conclusion
Do not split Trintellix tablets. Use the tablet strength prescribed, and if you have any concerns or need a different dose, consult your healthcare provider for guidance or alternatives.
This is not all the information you need to know about Trintellix for safe and effective use and does not take the place of your doctor’s directions. Review the full patient medication guide and discuss this information and any questions you have with your doctor or other health care provider.
References
- Espinosa, J., Meister, G., Rattu, M., & Lucerna, A. (2023). The Risks of Patient Pill Splitting: A Case Report and Review. Cureus, 15(11), e48610. https://doi.org/10.7759/cureus.48610
- Trintellix [package insert]. Updated March 2025. Takeda Pharmaceuticals America, Inc. Accessed on August 7, 2025 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a5b68e2-14d0-419d-9ec6-1ca97145e838
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Drug information
- Trintellix Information for Consumers
- Trintellix prescribing info & package insert (for Health Professionals)
- Side Effects of Trintellix (detailed)
- Trintellix user reviews (1,135)
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