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Can Trintellix be split or cut in half?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on Aug 8, 2025.

Official Answer by Drugs.com

No, Trintellix tablets should not be cut in half. They are film-coated and specifically designed to be taken whole to ensure you receive the accurate dose and proper absorption of the medication.

Why Splitting Trintellix Tablets Is Not Recommended

Trintellix (also known as vortioxetine) tablets have a film coating that serves several important purposes:

What If the Prescribed Dose Isn’t Available?

If your prescribed dose is not available, you should not attempt to split or cut Trintellix tablets.
Trintellix is available in several strengths, such as 5 mg, 10 mg, and 20 mg, to suit different dosing needs. If your required dose isn’t readily available, speak to your doctor or pharmacist. They can prescribe the correct strength or offer alternative solutions based on your treatment plan.

Related questions

Manufacturer and FDA Guidance

Official prescribing information and the FDA-approved label for Trintellix do not support splitting or crushing the tablets. The FDA-approved medication guide can be found on resources like Drugs.com or the official FDA website.

Safe Medication Practices

Conclusion

Do not split Trintellix tablets. Use the tablet strength prescribed, and if you have any concerns or need a different dose, consult your healthcare provider for guidance or alternatives.

This is not all the information you need to know about Trintellix for safe and effective use and does not take the place of your doctor’s directions. Review the full patient medication guide and discuss this information and any questions you have with your doctor or other health care provider.

References
  1. Espinosa, J., Meister, G., Rattu, M., & Lucerna, A. (2023). The Risks of Patient Pill Splitting: A Case Report and Review. Cureus, 15(11), e48610. https://doi.org/10.7759/cureus.48610
  2. Trintellix [package insert]. Updated March 2025. Takeda Pharmaceuticals America, Inc. Accessed on August 7, 2025 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a5b68e2-14d0-419d-9ec6-1ca97145e838

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