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How long does Lonsurf increase survival in colorectal cancer?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Aug 8, 2023.

Official Answer by Drugs.com

Key Points

In studies, Lonsurf has been shown to extend survival in patients with colorectal cancer that has spread (metastatic cancer) when used either as a single drug (median survival of 7.1 months) or when combined with bevacizumab (median survival of 10.8 months).

Study 1. Lonsurf compared to placebo

Study 2: Lonsurf + bevacizumab compared to Lonsurf alone

What is Lonsurf?

Lonsurf is classified as a nucleoside metabolic inhibitor which is incorporated directly into DNA and interferes with its function. The blood level of trifluridine is maintained by the enzyme inhibitor tipiracil.

Lonsurf is manufactured by Taiho Oncology.

Related questions

What are the most common side effects with Lonsurf?

Common side effects reported with Lonsurf include:

Lonsurf can also cause common and serious side effects such as anemia (low red blood cells), neutropenia (low white blood cells), and thrombocytopenia (low blood platelets). Low white blood cells can make you more likely to have a serious infection that may lead to death. Your doctor will periodically check your blood cell counts.

It is not known if Lonsurf is safe or effective in children. Tell your doctor if you are pregnant or plan to become pregnant because Lonsurf can harm your unborn baby. Females should use effective birth control during and for 6 months after the last dose of treatment with Lonsurf.

This is not all the information you need to know about Lonsurf (trifluridine and tipiracil) for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Lonsurf information here, and discuss this information and any questions you have with your doctor or other health care provider.

References

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