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What is the routine prophylaxis dosing regimen for Jivi?

Medically reviewed by Last updated on Sep 26, 2022.

Official answer


For routine prohylaxis to prevent bleeding, the recommended initial dosing regimen for Jivi is 30 to 40 international units (IU) per kilogram (kg) given intravenously twice weekly.

Jivi (antihemophilic Factor [recombinant], PEGylated-aucl) is an injectable medicine from Bayer Health Care used to replace clotting factor (Factor VIII or antihemophilic factor) that is missing in people with hemophilia A. It is used to treat and control bleeding in previously treated adults and adolescents (12 years of age and older).

Based on the bleeding episodes:

  • The regimen may be adjusted to 45 to 60 IU/kg every 5 days.
  • Jivi can be further individually adjusted to less or more frequent dosing based on bleeding episodes.

The FDA also approved Jivi for on-demand bleeding control and the perioperative (at or around the time of surgery) management of bleeding in the same population. See the labeling for Jivi to fully review dosing recommendations prior to use.

Drug information

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