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How is Nplate (romiplostim) administered?

Medically reviewed by Philip Thornton, DipPharm. Last updated on March 28, 2025.

Official Answer by Drugs.com

Nplate (romiplostim) is a once-weekly subcutaneous (under the skin) injection that is administered by a healthcare provider. It is used to treat thrombocytopenia in certain patients with immune thrombocytopenia (ITP) who have not responded adequately to corticosteroids, immunoglobulins, or splenectomy.

How is Nplate prepared?

Healthcare providers prepare Nplate by reconstituting the powder contained in a vial. The process includes:

How will I receive Nplate?

Your healthcare provider will use a syringe to draw up the required dose of Nplate from the vial containing the reconstituted powder. It will then be injected under your skin (subcutaneously) at one of three recommended injection sites:

A syringe with 0.01 mL graduations is used for precise dosing, as Nplate doses may be very small.

What Is the Usual Nplate Dosage?

Once your healthcare provider has determined what your regular dose of Nplate should be a blood test is only required once a month. Blood tests are also required for at least two weeks after treatment with Nplate is stopped to check your platelet counts aren’t dropping too low.

Is Nplate Used for Radiation Exposure?

Yes. Nplate (10 mcg per kg) can be administered as a one-time treatment to improve survival in individuals acutely exposed to myelosuppressive radiation doses (Hematopoietic Syndrome of Acute Radiation Syndrome, HS-ARS).

This FAQ provides general information about Nplate, but does not replace professional medical advice. Always follow your healthcare provider’s instructions and review the full prescribing information before starting treatment.

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