Can hydroxyzine be taken long-term?

Hydroxyzine is intended for short-term use only (less than 4 months) when used to treat anxiety. Using hydroxyzine long-term would be considered an off-label use for the drug because there are no studies looking at the long-term effects of hydroxyzine. Some research suggests a link between long-term use of medications with anticholinergic properties, such as hydroxyzine, and dementia, particularly in older adults. Brain fog has also been reported with long-term use.

Other conditions that hydroxyzine may be prescribed for, such as itchy skin due to an allergy, hives, dermatitis, or eczema, or as a sedative before surgery or other procedures, are generally short-lived and there is no need to prescribe hydroxyzine long-term.

See also:

Related medical questions

• Can you take hydroxyzine for anxiety and sleep?
• Does Benadryl help with or cause anxiety?
• Can dogs take hydroxyzine?
• When can I start drinking if I’m no longer taking hydroxyzine?
• Can you take antihistamines when pregnant?

Drug information

• Hydroxyzine Information for Consumers
• Hydroxyzine prescribing info & package insert (for Health Professionals)
• Side Effects of Hydroxyzine (detailed)
• Hydroxyzine user reviews (1,408)

Related support groups

• Hydroxyzine (109 questions, 203 members)

Medical Disclaimer