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How do you avoid Ozempic butt?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on March 19, 2025.

Official Answer by Drugs.com

Key Points

What is Ozempic butt?

"Ozempic butt" refers to sagging or deflated buttocks that some people experience after significant and rapid weight loss while taking Ozempic (semaglutide). This happens when fat loss occurs rapidly, and the skin does not have enough time to adjust, leading to a looser, less firm appearance.

What Causes Ozempic Butt?

Several factors contribute to the severity of "Ozempic butt," including:

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How to Prevent Ozempic Butt

While it’s difficult to predict if you will experience this effect, there are steps you can take to reduce the risk:

If you’re concerned about changes in body composition while taking Ozempic, consult your healthcare provider. They can offer personalized guidance on weight loss strategies, exercise routines, and skin health to help you achieve your health goals while minimizing unwanted effects.

References

Keen, M. A., et. al. (2016). Vitamin E in dermatology. In: Indian Dermatology Online Journal. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976416/

Ashtray-Larky, D., et. al. (2017). Rapid Weight Loss vs. Slow Weight Loss: Which is More Effective on Body Composition and Metabolic Risk Factors? In: International Journal of Endocrinology and Metabolism. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702468/

Humphrey, C. D., et. al. (2023). Implications of Ozempic and Other Semaglutide Medications for Facial Plastic Surgeons. In: Facial Plastic Surgery. Available from: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2148-6321

Neto, W. K., et. al. (2020). Gluteus Maximus Activation during Common Strength and Hypertrophy Exercises: A Systematic Review. In: Journal of Sports Science and Medicine. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039033/

Papakonstantinou, E., et. al. (2012). Hyaluronic acid: A key molecule in skin aging. In: Dermato Endocrinology. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/

Read next

How do Ozempic, Mounjaro, Wegovy, Zepbound compare for weight loss?

Ozempic, Mounjaro, Wegovy and Zepbound can all lead to long-term weight loss, but only Wegovy and Zepbound are approved by the FDA for this use. In studies, Zepbound has led to a 21% weight loss in adults using the highest dose, while Wegovy has led to about a 15% weight loss. Continue reading

How long does it take for Ozempic to work?

Your blood glucose (sugar) levels should start to fully decline within the first week after you start using Ozempic (semaglutide) at your regular dose. However, the full effect can take 8 weeks or longer, as this is a long-acting medication that is injected only once per week. Continue reading

Wegovy vs Ozempic: Which is Right for You?

Both Wegovy and Ozempic contain semaglutide, but Wegovy is prescribed for long-term weight management while Ozempic is used to control blood sugar levels in type 2 diabetes and help protect kidney function. They both lower the risk for heart-related complications, but they differ in other approved uses, doses, target populations and costs. Continue reading

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