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How long after you stop taking Accutane will it still stay in your system and cause any problems?

Medically reviewed by Last updated on Nov 2, 2020.

Official answer


It takes 5.5 x elimination half-life of a medicine before it is eliminated from your system.
Accutane (isotretinoin) has an elimination half-life of 21 hours, therefore it will take 5.5 x 21 hours = 115.5 hours (approximately 4.8 days) before it will be cleared from your system. Side effects may last longer. You must not become pregnant for 1 month after stopping Accutane.

However other factors to consider include:
1. How much and how often you have taken the drug.
2. Your metabolic rate – a slower metabolism will increase the time a drug remains in your system.
3. Your age and health – older age and poor health will generally increase the time the drug stays in your system.
4. Body mass – generally the bigger you are the longer a drug will remain in your system.

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