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How is fabrazyme administered/infused?

Medically reviewed by Carmen Fookes, BPharm. Last updated on Aug 16, 2021.

Official answer

by Drugs.com

Fabrazyme is given by intravenous infusion every two weeks by a healthcare provider. How long the infusion of Fabrazyme takes depends on how well you tolerate Fabrazyme and your weight.

Fabrazyme can cause infusion-associated reactions, such as chills, vomiting, low blood pressure, or paresthesia (burning or prickling sensations, usually in the hands), so your healthcare provider will start the infusion off slowly, at around 15mg per hour. This rate may be increased if you tolerate the infusion well and you weigh more than 30kg.

The minimum infusion duration for people weighing more than 30kg is 1.5 hours.

For people weighing less than 30kg, the maximum infusion rate is 15mg/hour, which means for a child weighing 20kg the infusion will take at least 80 minutes.

Fabrazyme is a recombinant human α-galactosidase A enzyme called agalsidase beta that may be used to treat Fabry disease in adults and children aged 2 years and older. It has the same amino acid sequence as the naturally-occurring enzyme called alpha-galactosidase A (or alpha-GAL).

References
  • Fabrazyme (agalsidase beta) [Product information]. Updated 03/2021. Sanofi Genzyme https://www.drugs.com/pro/fabrazyme.html
  • Fabrazyme. Fabrazyme.com 2021.

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