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How is Enspryng administered?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Feb 3, 2025.

Official Answer by Drugs.com

Enspryng is given as an injection under the skin (a subcutaneous injection) in the thigh or stomach area to treat neuromyelitis optica spectrum disorder (NMOSD) in adults. Your healthcare provider can teach you how to give these injections at home. After the first 3 doses given 2 weeks apart, you will administer one injection every 4 weeks thereafter.

Your healthcare professional will teach you or your caregiver how to inject Enspryng. You may also receive injections from your healthcare provider if you prefer. Do not inject the medicine until you have received proper training.

Why is Enspryng given?

Enspryng (satralizumab-mwge) is approved by the FDA for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive.

What is neuromyelitis optica spectrum disorder (NMOSD)?

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system that leads to inflammation (swelling) in the nerves of the eye and the spinal cord. It occurs when the immune system attacks your own cells. It can occur after an infection or may be related to another autoimmune disease.

NMOSD can cause blindness, weakness in the arms or legs, painful spasms, numbness, uncontrollable vomiting and hiccups, and bladder or bowel trouble. Confusion, seizures, or comas can occur in children.

Tips for using Enspryng

Keep the unused syringe in the refrigerator between 36°F to 46°F (2°C to 8°C) until you are ready to use it. Do not freeze. Take the Enspryng carton out of the refrigerator about 30 minutes before injection time, this way it will warm up to room temperature and will be a more comfortable injection. Keep the carton and syringe away from sunlight, heat and any moisture.

If the Enspryng package has not been opened, it can be taken out of the refrigerator and put back, if needed, over time. Keep the syringe in its original package. The total combined time out of the refrigerator should not be more than 8 days at a temperature that does not go above 86°F (30°C).

The syringe has a needle-shield that automatically covers the needle when the injection is complete to help prevent accidental needle sticks. Do not replace the needle cover after removing it. You may also damage the needle.

Do not insert the syringe needle through your clothing, change the angle of the injection, or insert the needle again after injection.

Put your used syringe in an FDA-cleared sharps disposal container immediately after use. Do not throw away (dispose of) the syringe in your household trash.

If you have stopped treatment for a side effect or infection, carefully follow your doctor's instructions about the schedule for restarting the medicine.

Where do you inject Enspryng?

How do you administer / inject Enspryng?

For more information on how to administer this medicine and see printed diagrams, review the “Instructions for Use” found in the Enspryng Patient Counseling information.

Before you inject this medicine for the first time, you should have received training from a healthcare professional.

This information does not take the place of talking to your healthcare provider about your medical condition, treatment or how to administer this medicine.

Bottom line

This is not all the information you need to know about Enspryng (satralizumab-mwge) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

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