How effective is Xywav for Idiopathic Hypersomnia?
Xywav stops people with idiopathic hypersomnia from feeling sleepy during the day with an average improvement in the Epworth Sleepiness Scale (ESS) of 7 points. The ESS is a subjective measure of your risk of falling asleep during activities such as watching TV, talking to someone, or while in a car. Scores range from 0 (no chance of dozing) to 24 (excessive sleepiness requiring medical attention). A score of 10 or higher suggests idiopathic hypersomnia.
Clinical Trials:
- Trials looking at the effectiveness of Xywav administered it to everybody to start with, then stopped it for approximately half of the participants.
- The median improvement in ESS score was 6.5 in those who took Xywav compared to 5 in those taking a placebo (an inactive treatment) during the stable dose period.
- At the end of the double-blind withdrawal period, the difference in ESS between those who stopped Xywav and those who kept taking it was 7 points, indicating a worsening of daytime sleepiness in those who stopped it.
Patient Outcomes:
- 79% of those that took Xywav said their symptoms of idiopathic hypersomnia, such as long sleep time, cognitive impairment, and sleep inertia, improved.
What is Idiopathic Hypersomnia?
Idiopathic hypersomnia is a condition that causes you to be very sleepy during the day even after a good night’s sleep. It can also cause difficulty waking up after you've been asleep.
References
- Study results with XYWAV IH Xywav.com https://www.xywav.com/idiopathic-hypersomnia/xywav-efficacy/
- Xywav (sodium oxybate, calcium oxybate, potassium oxybate, and magnesium oxybate) Updated 10/2022. Jazz Pharmaceuticals, Inc. https://www.drugs.com/pro/xywav.html#s-34092-7
Read next
Xywav vs Xyrem: What's the difference between them?
Xywav is a low-sodium alternative to Xyrem, approved in 2020 after concerns about the high sodium content of Xyrem potentially contributing to heart disease. Continue reading
Can you have narcolepsy and insomnia?
Yes, you can have narcolepsy and insomnia together. Almost 50% of people with narcolepsy also experience disturbed night-time sleep, fragmented sleep, or difficulty staying asleep at night. Sleep may be disrupted by insomnia, vivid dreaming, sleep apnea, acting out while dreaming, or periodic leg movements. Continue reading
What is the difference between narcolepsy and idiopathic hypersomnia?
Although narcolepsy and idiopathic hypersomnia both have excessive daytime sleepiness as a common symptom, people with idiopathic hypersomnia have no sleep-onset rapid eye movement (REM) period, naps are unrefreshing (unlike with narcolepsy) and idiopathic hypersomnia is not associated with cataplexy. Idiopathic hypersomnia can be difficult to distinguish from narcolepsy, but sleep laboratory studies can help differentiate between them. Continue reading
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Drug information
- Xywav (16 reviews)
- Calcium Oxybate / magnesium Oxybate / potassium Oxybate / sodium Oxybate (17 reviews)
Related support groups
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