How effective is Xywav for Idiopathic Hypersomnia?

Xywav stops people with idiopathic hypersomnia from feeling sleepy during the day with an average improvement in the Epworth Sleepiness Scale (ESS) of 7 points. The ESS is a subjective measure of your risk of falling asleep during activities such as watching TV, talking to someone, or while in a car. Scores range from 0 (no chance of dozing) to 24 (excessive sleepiness requiring medical attention). A score of 10 or higher suggests idiopathic hypersomnia.

Clinical ​Trials:

• Trials looking at the effectiveness of Xywav administered it to everybody to start with, then stopped it for approximately half of the participants.
• The median improvement in ESS score was 6.5 in those who took Xywav compared to 5 in those taking a placebo (an inactive treatment) during the stable dose period.
• At the end of the double-blind withdrawal period, the difference in ESS between those who stopped Xywav and those who kept taking it was 7 points, indicating a worsening of daytime sleepiness in those who stopped it.

Patient Outcomes:

• 79% of those that took Xywav said their symptoms of idiopathic hypersomnia, such as long sleep time, cognitive impairment, and sleep inertia, improved.

What is Idiopathic Hypersomnia?

Idiopathic hypersomnia is a condition that causes you to be very sleepy during the day even after a good night’s sleep. It can also cause difficulty waking up after you've been asleep.