Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Adrenocot LA (dexamethasone)
- aminoglutethimide
Interactions between your drugs
dexAMETHasone aminoglutethimide
Applies to: Adrenocot LA (dexamethasone), aminoglutethimide
GENERALLY AVOID: Aminoglutethimide may significantly increase dexamethasone clearance by induction of CYP450 3A4 hepatic microsomal enzymes. An increase of 292% in dexamethasone clearance has been reported. It is unknown whether other corticosteroids would be affected to the same extent.
MANAGEMENT: Dexamethasone should not be used in patients receiving aminoglutethimide for adrenal suppression. If glucocorticoid replacement is necessary, hydrocortisone is recommended as an alternative because it does not appear to interact.
References (2)
- Kvinssland S, Lonning PE, Ueland PM (1986) "Aminoglutethimide as an inducer of microsomal enzymes. Part 1: Pharmacological aspects." Breast Cancer Res Treat, 7, s73-6
- (2002) "Product Information. Cytadren (aminoglutethimide)." Ciba Self-Medication Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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