Drug Interaction Report
1 drug interaction and 10 additional warnings found for the following 2 drugs:
- repotrectinib
- treosulfan
Drug interactions
Moderate drug interactions
Moderate:treosulfan repotrectinib
Applies to: treosulfan, repotrectinib
Treosulfan may increase the blood levels of repotrectinib.
This may increase the risk and/or severity of side effects such as dizziness, tiredness, muscle pain, nausea, change in your sense of taste, feeling numbness or tingling in your arms or legs, constipation, trouble with balance, shortness of breath, problems with thinking such as forgetfulness or confusion and hallucinations, as well as more serious side effects such as severe or life-threatening inflammation of the lungs and liver injury.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:Food/Lifestyle repotrectinib
Applies to: repotrectinib
Consumption of grapefruit, grapefruit juice, supplements that contain grapefruit, and Seville oranges should be avoided during treatment with repotrectinib as they may increase the blood levels of repotrectinib.
This may increase the risk and/or severity of side effects such as:
- dizziness
- tiredness
- muscle pain
- nausea
- change in your sense of taste
- feeling numbness or tingling in your arms or legs
- constipation
- trouble with balance
- shortness of breath
- problems with thinking such as forgetfulness or confusion and hallucinations
- as well as more serious side effects such as severe or life-threatening inflammation of the lungs and liver injury
Talk to your doctor if you have any questions or concerns. Your doctor may be able to provide alternatives that do not interact.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
9 potential interactionsApplies to: 7 conditions, including Asthma, COPD, Seizures, Liver Disease, and Interstitial Lung Disease.
Asthma
Moderate:repotrectinib
Repotrectinib has a moderate potential interaction with Asthma.
Repotrectinib can cause interstitial lung disease (ILD)/pneumonitis. This may be considered in patients with lung or breathing problems other than lung cancer. Patients should be monitored for new/worsening pulmonary symptoms indicative of ILD/pneumonitis and should be advised to contact their health care provider if such symptoms develop.
COPD
Moderate:repotrectinib
Repotrectinib has a moderate potential interaction with COPD.
Repotrectinib can cause interstitial lung disease (ILD)/pneumonitis. This may be considered in patients with lung or breathing problems other than lung cancer. Patients should be monitored for new/worsening pulmonary symptoms indicative of ILD/pneumonitis and should be advised to contact their health care provider if such symptoms develop.
Interstitial Lung Disease
Moderate:repotrectinib
Repotrectinib has a moderate potential interaction with Interstitial Lung Disease.
Repotrectinib can cause interstitial lung disease (ILD)/pneumonitis. This may be considered in patients with lung or breathing problems other than lung cancer. Patients should be monitored for new/worsening pulmonary symptoms indicative of ILD/pneumonitis and should be advised to contact their health care provider if such symptoms develop.
Liver Disease
Moderate:repotrectinib
Repotrectinib has a moderate potential interaction with Liver Disease.
Repotrectinib can cause hepatotoxicity; this may be considered in patients with liver problems. The effect of moderate or severe liver dysfunction (total bilirubin greater than 1.5 times the upper limit of normal and any AST) on repotrectinib pharmacokinetics is unknown. The recommended dosage of repotrectinib has not been established in patients with moderate or severe liver dysfunction.
Moderate:treosulfan
Treosulfan has a moderate potential interaction with Liver Disease.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Neurological Disorders
Moderate:repotrectinib
Repotrectinib has a moderate potential interaction with Neurological Disorders.
Repotrectinib can cause central nervous system (CNS) adverse reactions including dizziness, ataxia, cognitive disorders, mood disorders, and sleep disorders. This may be considered in patients with neurological problems. Patients should be advised to contact their health care provider for new/worsening CNS symptoms.
Renal Dysfunction
Moderate:repotrectinib
Repotrectinib has a moderate potential interaction with Renal Dysfunction.
The effect of severe renal dysfunction, kidney failure (estimated GFR less than 30 mL/min), or dialysis on repotrectinib pharmacokinetics is unknown. The recommended dosage of repotrectinib has not been established in patients with severe renal dysfunction or kidney failure or in patients on dialysis.
Moderate:treosulfan
Treosulfan has a moderate potential interaction with Renal Dysfunction.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Seizures
Moderate:treosulfan
Treosulfan has a moderate potential interaction with Seizures.
There have been reports of seizures in patients following treatment with treosulfan. Patients should be monitored for signs of neurological adverse reactions, and clonazepam prophylaxis may be considered for patients at higher risk for seizures, including infants.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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