Drug Interaction Report

Using abametapir topical together with naloxegol should be avoided if possible. Combining these medications may increase the blood levels and effects of naloxegol. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring to safely use both medications. You should seek immediate medical attention if you develop any increase in side effects to naloxegol. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Do not consume grapefruit or grapefruit juice during treatment with naloxegol. Grapefruit juice can significantly increase the blood levels of naloxegol. You may be more likely to experience side effects and withdrawal symptoms such as sweating, tearing, runny nose, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning. Taking naloxegol with food can also increase its absorption into the blood stream. Therefore, you should take it on an empty stomach at least 1 hour before or 2 hours after a meal. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.