Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- amoxicillin / omeprazole / rifabutin
- Otezla (apremilast)
Interactions between your drugs
rifabutin apremilast
Applies to: amoxicillin / omeprazole / rifabutin, Otezla (apremilast)
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of apremilast, which is primarily metabolized by the isoenzyme in vitro. According to the product labeling, administration of a single 30 mg oral dose of apremilast with the potent CYP450 inducer rifampin (600 mg once daily for 15 days) resulted in decreases of apremilast peak plasma concentration (Cmax) and systemic exposure (AUC) by 43% and 72%, respectively.
MANAGEMENT: The possibility of a diminished therapeutic response to apremilast should be considered during coadministration with CYP450 3A4 inducers. Pharmacologic effects of apremilast should be monitored more closely following the initiation or withdrawal of a CYP450 3A4 inducer.
References (1)
- (2014) "Product Information. Otezla (apremilast)." Celgene Corporation
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Protonix
Protonix (pantoprazole) is used to treat erosive esophagitis and other conditions involving excess ...
Nexium
Nexium is used to treat GERD and other conditions involving excessive stomach acid. Learn about ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Prilosec
Prilosec (omeprazole) is used to treat symptoms of GERD and other conditions caused by excess ...
Flagyl
Flagyl is used to treat bacterial infections of the vagina, stomach, skin and joints. Learn about ...
Amoxil
Amoxil (amoxicillin) is a penicillin antibiotic used to treat many different types of infections ...
Pepto-Bismol
Pepto-Bismol is antacid used to treat heart burn, indigestion, diarrhea, gas or an upset stomach ...
Prevacid
Prevacid is used to treat and prevent stomach and intestinal ulcers. Learn about side effects ...
Aciphex
Aciphex is used to treat gastroesophageal reflux disease (GERD) and other conditions involving ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.